血液灌流联合血液透析治疗尿毒症患者的临床效果及其对肾功能的影响

Clinical efficacy of hemoperfusion combined with hemodialysis on uremic patients and its effect on renal function

目的探讨血液灌流联合血液透析治疗尿毒症患者的临床效果及对其肾功能的影响。方法选取2017年6月至2018年10月在我院接受治疗的尿毒症患者65例,根据数字随机表法分为对照组(32例)和观察组(33例)。对照组患者采用血液透析治疗,观察组采用血液灌流联合血液透析治疗。持续治疗8周后,比较两组患者的临床疗效,检测比较两组患者的血尿素氮(BUN)、血肌酐(Scr)以及甲状旁腺腺素(PTH)水平。结果观察组的治疗总有效率(93.9%)明显高于对照组(75.0%),差异有统计学意义(P<0.05)。治疗前,两组患者的BUN、Scr、PTH水平比较差异无统计学意义(P>0.05);治疗8周后,两组患者的BUN、Scr、PTH水平均明显降低,观察组上述指标水平均显著低于对照组,差异有统计学意义(P<0.05)。结论血液灌流联合血液透析治疗尿毒症患者临床效果确切,同时可显著改善患者的肾功能。

Objective To explore the clinical efficacy of hemoperfusion combined with hemodialysis on uremic patients and its effect on renal function.Methods A total of 65 patients with uremia who were treated in our hospital from June 2017 to October 2018 were selected and randomly divided into control group (32 cases) and observation group ( 33 cases ).The control group was treated with hemodialysis,and the observation group was treated with hemoperfusion combined with hemodialysis.After 8 weeks of continuous treatment,the clinical efficacy of the two groups was compared,and the blood urea nitrogen (BUN),serum creatinine (Scr) and parathyroid hormone (PTH) levels were compared between the two groups.Results The total effective rate of treatment in the observation group (93.9%) was significantly higher than that in the control group (75.0%),and the difference was statistically significant ( P <0.05).Before treatment,there was no statistically significant difference in BUN,Scr and PTH levels between the two groups ( P >0.05).After 8 weeks of treatment,the BUN,Scr and PTH levels in both groups decreased significantly,and the level of the above indexes in the observation group was significantly lower than that in the control group,and the difference was statistically significant ( P <0.05 ).Conclusion Hemoperfusion combined with hemodialysis on treating uremia patients has definitely clinical effect;meanwhile,it can significantly improve the renal function of patients.