化痰消瘀剂治疗胃部癌前病变的效果评价

Impact evaluation of Hua-Tan-Xiao-Yu decoction in the treatment of gastric precancerous lesions

目的探讨化痰消瘀汤剂对胃癌前病变患者的临床疗效。方法选取本院120例胃癌前病变患者,用随机数字表法分为两组各60例,两组均采用奥美拉唑肠溶胶囊、铝碳酸镁片治疗,观察组在此基础上采用化痰消瘀汤剂治疗,比较两组的临床疗效、中医证候积分、血清肿瘤标志物含量、生存质量评分、不良反应发生率。结果观察组临床总有效率高于对照组(P<0. 05)。治疗后,两组患者的胃脘胀痛、大便溏稀、嗳气反酸、食欲减退等中医证候积分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0. 05)。治疗后,两组患者的血清癌胚抗原(CEA)、糖类抗原125(CA125)、CA199、胃癌抗原(CA724)含量均较治疗前降低,且观察组低于对照组,差异有统计学意义(P<0. 05)。两组治疗后的生存质量评分均较治疗前提高,且观察组高于对照组,差异有统计学意义(P<0. 05)。两组不良反应发生率比较,差异无统计学意义(P>0. 05)。结论采用化痰消瘀汤剂治疗胃癌前病变可促使患者症状缓解,降低其血清CEA、CA125等肿瘤标志物的表达水平,有利于控制病情进展,提高疗效,提高生存质量,且不会增加不良反应风险,安全性可靠。

Objective To investigate the clinical effect of Hua-Tan-Xiao-Yu decoction in the treatment of gastric precancerous lesions.Methods One hundred and twenty patients with gastric precancerous lesions were randomly divided into observation or control group,60 in each group.All patients were treated with omeprazole enteric-coated capsule and magnesium bicarbonate tablets.On this basis,the observation group was treated with Hua-Tan-Xiao-Yu decoction while the control group was not treated with other drugs. The clinical efficacy,TCM syndromes score,serum tumor marker content,quality of life score and adverse reaction rate were compared between the two groups. Results Total clinical efficiency in the observation group was higher than that in the control group (P<0. 05).After treatment,the TCM syndromes such as epigastric distension pain,loose stool,anti-acid belching and loss of appetite were lower than those before treatment in the two groups (P<0. 05),and the TCM syndromes in the observation group were lower than those in the control group (P<0. 05).After treatment,serum levels of CEA,CA125,CA199,and CA724 of both groups were lower than before treatment (P<0. 05),and the levels of CEA,CA125,CA199,and CA724 in the observation group were lower than those in the control group (P<0. 05).After treatment,both groups had higher quality of life scores than before treatment (P<0. 05),and the observation group had higher quality of life scores in all aspects than the control group (P< 0. 05).There was no significant difference in the total incidence rate of adverse reaction between the two groups (P>0. 05).Conclusion The treatment of gastric precancerous lesions with HuaTan-Xiao-Yu decoction can relieve the symptoms,decrease the expression level of tumor markers,control the progress of the disease,improve the curative effect and improve the quality of life of the patients.It does not increase the risk of adverse reactions.The safety is reliable.