肝纤维化的影像学定量技术进展评述

Advances of imaging quantitative techniques for liver fibrosis

肝纤维化是慢性肝病的一个重要标志。对肝纤维化的早期诊断、干预,有助于延缓其发展甚至逆转病程。目前肝纤维化诊断的金标准是肝穿刺活检,穿刺活检有助于明确肝纤维化的诊断及分期,但穿刺活检同样存在一定的局限性,例如取样误差及一系列潜在并发症。近年来,分子影像定量检测技术发展迅速,在肿瘤成像等领域发挥出了重要的作用,其在肝纤维化定量检测中的应用,也受到越来越多的重视。笔者回顾目前主流分子影像成像方法在肝纤维化定量诊断中的应用,对其优缺点进行概述,以加深临床工作者对这些检查手段的认知。

Liver fibrosis is an important sign of chronic liver diseases. Liver fibrosis could be treated and even reversed if detected in early stages. At present,the gold standard for the diagnosis of liver fibrosis is liver biopsy,which is helpful for the diagnosis and staging of liver fibrosis. However,it also has some limitations,such as sampling error and a series of potential complications. In recent years,molecular imaging quantitative detection technology has developed rapidly and played an important role in tumor imaging and other fields. The application in the quantitative detection of liver fibrosis has also received more and more attention. In this review,the current application of molecular imaging in the quantitative diagnosis and staging of liver fibrosis was summarized,and the advantages and disadvantages to facilitate the better and more comprehensive understanding of these techniques were also discussed.