自然流产的遗传学检测研究进展

Advances in genetic testing of spontaneous abortion

临床导致自然流产(SA)的病因复杂,其中染色体异常是主要原因。对流产物进行染色体异常排查,不仅可以明确本次流产的原因,还可以通过结合遗传咨询及辅助生殖手段指导再次妊娠。随着分子生物学技术的发展,自然流产的遗传学检测方法也越来越多,各具优势。近年来发展起来的高通量检测方法不仅可以一次性扫描全部染色体,而且提高了自然流产检测的成功率和准确性。本文就SA的遗传学检测技术研究进展进行综述,旨在为临床选择合适的染色体异常检测技术提供参考。

Spontaneous Abortion(SA)has a complex etiology,and chromosomal abnormalities are the main cause of SA. The chromosomal abnormality of the convective products can not only clarify the cause of the abortion,but also guide the re.pregnancy by combining genetic counseling and assisted reproductive means. With the development of molecular biology,there are more and more genetic methods to test abortion tissue with their own advantages. The high.throughput technique developed in recent years can scan all chromosomes at one time,and improve the success rate and detection accuracy. This review summarizes the advances on the SA detection in molecular biology technique,in order to provide a reference for selecting proper chromosomal abnormality detection technologies.