Prohibitin在结直肠癌组织中表达及其与预后的关系

Correlation analysis of expression pattern and prognosis of Prohibitin in colorectal cancer tissue

目的观察Prohibitin(PHB)在结直肠癌组织中表达及其与预后的关系。方法 400例结直肠癌标本用免疫组化检测PHB表达,分析其与预后的关系。结果 PHB表达与肿瘤部位(结肠、直肠)及血管侵犯有关(P<0.01或0.05),但与性别、年龄、肿瘤大小及分化程度、临床分期、淋巴结转移无关(P>0.05)。PHB呈离心性表达者的预后明显差于向心性表达者(P<0.01)。结论 PHB表达涉及结直肠癌部位及血管侵犯,离心性表达者提示预后不良。

Objective To study the relationship between prohibitin expression and prognosis in colorectal cancer tissue. Methods Prohibitin expression was determined by immunohistochemistry in 400 cases of colorectal cancer, and its relationship with prognosis was analyzed. Results Prohibitin expression was associated with tumor sites and vascular invasion (P<0.01 or 0.05), but not with gender, age, tumor size and differentiation, clinical grade, and node metastasis (P>0.05). Prognosis was worse in patients with centrifugal PHB expression compared with centripetal expression (P<0.01). Conclusion Prohibitin expression is involved in tumor sites and vascular invasion, and its centrifugal expression suggests poor prognosis in colorectal cancer.