复方米诺环素奥硝唑温敏凝胶治疗慢性牙周炎的效果评价

Evaluation on Efficacy of Thermosensitive Minocycline and Omidazole Complex Gel in Treatment of Chronic Periodontitis

目的:评价复方米诺环素奥硝唑温敏凝胶治疗慢性牙周炎的临床效果。方法:选择慢性牙周炎患者132例,随机分为观察组和对照组,治疗组口腔局部使用复方米诺环素奥硝唑温敏凝胶;对照组局部使用米诺环素软膏,比较两组患者治疗效果、牙周炎指数变化情况、炎症因子水平和药物不良反应情况。结果:观察组总有效率为95.45%,对照组总有效率为83.33%,观察组牙周炎指数变化情况、炎症因子水平和药物不良反应均低于对照组,两两相比具有明显差异(P<0.05)。结论:比较对慢性牙周炎患者局部应用复方米诺环素奥硝唑温敏凝胶和米诺环素的治疗效果后发现,复方米诺环素奥硝唑温敏凝胶可有效改善患者临床症状,值得临床推广。

Objective: To evaluate the clinical effect of thermosensitive minocycline and omidazole complex gel on chronic periodontitis.Methods: A total of 132 patients with chronic periodontitis were recruited in this prospective study and were randomly divided into observation group ( n =66) and control group ( n =66).Patients in control group were given minocycline ointment and patients in observation group were given thermosensitive minocycline and omidazole complex gel.The therapeutic effect,changes of periodontitis index,inflammatory factor level,and adverse reaction in two groups were compared.Results: The total effective rates were 95.45% and 83.33% in observation and control groups,respectively;the changes of periodontitis index,inflammatory factor level,and adverse reaction in the observation group were lower than those in the control group ( P <0.05).Conclusion: The local application of thermosensitive minocycline and omidazole complex gel can effectively improve the clinical symptoms of patients with chronic periodontitis.