浓缩生长因子在上颌前牙区引导骨再生术中的临床应用

Clinical Application of Concentrated Growth Factors in Guided Bone Regeneration of Maxillary Anterior Region

目的:评价浓缩生长因子(concentrated growth factors,CGF)在上颌前牙区引导骨再生术中的临床疗效。方法:选取上颌单个前牙缺失伴唇侧牙槽骨缺损患者63例,随机分为实验组(32例)和对照组(31例)。实验组植入CGF+Bio-Oss骨粉,表面覆盖CGF膜,对照组植入Bio-Oss骨粉,表面覆盖海奥生物膜。分别于术前、术后即刻和术后6个月拍摄锥形束CT(cone beam computed tomography,CBCT),并于术前、术后6个月测量术区角化龈宽度,比较两组手术前后CBCT和临床数据的变化。结果:实验组与对照组水平骨宽度术后较术前均有明显增加,差异有统计学意义(P<0.01),实验组术后6个月水平骨增量显著高于对照组(P<0.05),实验组的骨吸收率明显低于对照组,差异有统计学意义(P<0.05)。实验组术后6个月角化龈宽度较术前显著增加,差异有统计学意义(P<0.05),对照组无明显变化(P>0.05)。结论:CGF应用于上颌前牙引导骨再生术中表现出了较强的软硬组织再生能力,是一种较理想的骨增量技术。

Objective: To evaluate the clinical effect of guided bone regeneration by using concentrated growth factors (CGF) in maxillary anterior region.Methods: 65 patients with single anterior tooth labial bone defect were enrolled and randomly divided into experimental group (32 cases) and control group (31 cases).The experimental group was treated with CGF combined with Bio-oss and covered with CGF membrane,and the control group was treated with Bio-oss and covered with biological membrane.Cone beam computed tomography (CBCT) was performed at baseline,immediate,and 6 months post-surgery,and the keratinized gingiva width was measured at baseline and 6 months post-surgery.The changes of clinical and CBCT data were compared between two groups.Results: There was a statistically significant increase in the horizontal bone width in both groups between baseline and post-surgery ( P <0.01).Six months postoperatively,the gain of horizontal bone in the experimental groups was significantly higher than that in the control group ( P <0.05).The test group showed statistically significantly lower bone absorption rate than the control group ( P <0.05).Six months after operation,there was a statistically significant increase in the keratinized gingiva width in the experimental group compared with baseline ( P <0.05),however,there were no changes in the control group ( P >0.05).Conclusion: The application of CGF in guided bone regeneration of maxillary anterior region showed better effect on the regeneration of the soft and hard tissue.