带状疱疹后遗神经痛研究进展

Research progress of postherpetic neuralgia

带状疱疹是由潜伏于脊髓后根神经节中的水痘-带状疱疹病毒被各种诱发因素再次激活所引起的急性感染性皮肤病。近年来,带状疱疹的发病率呈逐年上升趋势,而神经痛为该病的主要症状之一,其并发症以带状疱疹后遗神经痛(PHN)最常见且难于控制。目前为止,关于PHN尚无统一定义,且发病机制不明,治疗方法有限,这极大影响了患者的生活质量。本文将对PHN的定义、发病机制、危险因素及防治进行综述,以帮助临床医师及时预防本病的发生发展。

Herpes zoster is an acute skin infection caused by the reactivated latent varicella-zoster virus in the dorsal root ganglia of the spinal cord. Recent years have witnessed an increasing incidences of herpes zoster,and neuralgia is one of its main symptoms with post-herpetic neuralgia (PHN) being the most common and difficult complication to control. Until now,no universally accepted definition of PHN has been made,its pathogenesis remains unknown,and its treatment is limited,which exerts serious effects on patients′ quality of life. This article reviews PHN in the respects of its definition,pathogenesis,risk factors and treatment to facilitate its timely prevention and treatment.