静脉血栓栓塞及颅内静脉血栓形成与炎性反应关系的研究进展

Research progress on the correlation between inflammation and venous thromboembolism as well as cerebral venous thrombosis

既往大量证据表明,炎性反应与凝血密切相关,静脉血栓形成的病理生理机制不仅局限于凝血系统,炎性反应也参与静脉血栓的形成和溶解,最后影响疾病的结局。作者通过阅读大量文献,对炎性反应与凝血、炎性反应与静脉血栓栓塞及颅内静脉血栓形成的关系进行综述分析。炎性反性不仅是凝血及静脉血栓形成的原因,而且可发生于凝血及静脉血栓形成之后并促进疾病进展,提示抗炎治疗可能是静脉血栓栓塞及颅内静脉系统血栓形成的一种有效的治疗或预防措施。

Plenty of previous evidence indicated that inflammation may be closely associated with coagulation and the pathophysiology of venous thromboembolism is not restricted to the coagulation system .Inflammation may also contribute to thrombus formation and resolution so that it could finally influence the outcomes.Through reading literatures,we aimed to review the correlation of inflammation with aspects involving coagulation,venous thromboembolism,and cerebral venous thrombosis.Inflammatory is not only the cause of coagulation and venous thrombosis,but also subsequent reaction to promote disease progression.Thus,it is suggested that anti-inflammatory therapy may be an effective treatment or preventive measure for venous thromboembolism and cerebral venous thrombosis.