原发性高血压病的蒙医辨证分型与颈动脉粥样硬化的关系

The relationship between Mongolian dialectical classification of essential hypertension and carotid atherosclerosis

目的运用蒙医辨证分型,对原发性高血压病致早期动脉粥样硬化的形成进行探讨。方法2013年7月至2014年12月期间从内蒙古国际蒙医医院、内蒙古医科大学附属医院、内蒙古医科大学附属蒙中医院住院部及门诊收集符合诊断标准的原发性高血压病患者200例,进行蒙医辨证分型,分为赫依血偏盛型、巴达干赫依偏盛型、血希拉偏盛型、聚合型等4型,每型各50例,对入选的患者进行一般情况比较,并抽取入选患者清晨空腹静脉血,用ELISA酶标法分别测定血清一氧化氮(nitric oxide,NO)、血管紧张素转换酶2(angiotensin convertin genzyme2,ACE2)、高敏C反应蛋白(high-sensitivity C-reactive protein,HsCRP)浓度,采用PHILIPSiU22彩色多普勒超声诊断仪,测量颈动脉内膜-中层(intima-media thickness,IMT)厚度及是否形成斑块,根据所测得结果进行统计学比较。结果赫依血偏盛型、巴达干赫依偏盛型、血希拉偏盛型、聚合型4型间年龄、BMI、舒张压无统计学差异(P>0.05),性别、收缩压、压差、病程分布有统计差异(P<0.05),NO、ACE2、HsCPR浓度,LIMT、RIMT及斑块形成等均无统计学差异(P>0.05)。结论原发性高血压病蒙医各型均已形成颈动脉粥样硬化,但在蒙医各症型间无明显差异。

Objective By using Mongolian medicine dialectical types to investigate the early atherosclerosis induced by essential hypertension. Methods July 2013-December 2014 period from the Inner Mongolian International Hospital,Affiliated Hospital of Inner Mongolia University,Inner Mongolia Medical University Affiliated Hospital of inpatientand outpatient collected 200 cases of patients with essential hypertension,Conduct the Mongolian medicine dialectical types,Divided into the type of Hei Qisu piansheng,type of Badgan Hei piansheng,type of Qisu Xira piansheng,type of polymeric,And from the 4 types were randomly selected 50 patients with essential hypertension,the selected patients to comparing the general situation,the levels of serum nitric oxide (NO),angiotensin converting enzyme 2 (ACE2) and high sensitivity C-reactive protein (HsCRP) were measured by ELISA with the selected patients’ morning fasting blood and the thickness of the carotid intima - media (IMT) and the formation of plaques were measured by the PHILIPS iU22 color Doppler ultrasonography,and the results were statistically compared according to the measured results. Results There was no significant difference I,diastolic blood pressure( P >0.05),There were statistical differences in gender,systolic blood pressure,Pressure difference( P <0.05 ),And there was no significant difference in NO,ACE2,HsCPR concentration,LIMT,RIMT and plaque formation for the type of Hei Qisu piansheng,type of Badgan Hei piansheng,type of Qisu Xira piansheng,type of polymeric 4 types( P >0.05). Conclusion Hypertensive disease in all types have developed carotid atherosclerosis,but no significant difference in the Mongolia medicine various types.