RBP及mAlb等实验室指标检测对新生儿窒息肾损害的诊断价值

Diagnostic value of laboratory indicators such as RBP and mAlb in kidney damage of neonatal asphyxiated

目的分析RBP及mAlb等实验室指标检测对新生儿窒息肾损害的诊断价值。方法将我院2017年8月至2018年7月收治的既往有窒息史新生儿37例设为无肾损组,另将既往有窒息史且伴发肾损伤的37例新生儿设为肾损组,选择37例健康新生儿为对照组。检测并比较三组尿RBP、mAlb等实验室指标指标水平。结果肾损组和无肾损组的Netrin-1、RBP、mAlb及NGAL水平均显著高于对照组,且肾损组高于无肾损组,差异具有统计学意义(P<0.05)。肾损组和无肾损组的肾血流Vs、Vd均显著低于对照组,且肾损组低于无肾损组,差异具有统计学意义(P<0.05);肾损组和无肾损组的RI、PI均显著高于对照组,且肾损组高于无肾损组,差异具有统计学意义(P<0.05)。肾损组中,重度窒息亚组的RBP、mAlb、NAGL及Netrin-1水平显著高于轻度窒息亚组,差异具有统计学意义(P<0.05);肾损组中,重度窒息亚组的Vs、Vd均显著低于轻度窒息亚组,而RI、PI显著高于轻度窒息亚组,差异具有统计学意义(P<0.05)。结论将尿RBP及mAlb等实验室指标纳入窒息新生儿血清检测指标中有助于提高诊断准确性,值得临床推广应用。

Objective To analyze the diagnostic value of laboratory indicators such as RBP and mAlb in kidney damage of neonatal asphyxiated.Methods From August 2017 to July 2018,thirty-seven neonates with previous asphyxia history admitted in our hospital were divided into non-renal injury group,thirty-seven neonates with previous asphyxia history and renal injury were divided into renal injury group and 37 healthy neonates were selected as control group.The levels of urinary RBP,mAlb and other laboratory indicators in the three groups were detected and compared.Results The levels of Netrin-1,RBP,mAlb and NGAL in the renal injury group and non-renal injury group were significantly higher than those in the control group,and those in the renal injury group were higher than the non-renal injury group,the differences were statistically significant(P<0.05).The Vs and Vd of renal blood flow in the renal injury group and non-renal injury group were significantly lower than those in the control group,and those in the renal injury group were lower than the non-renal injury group,the differences were statistically significant(P<0.05);the RI and PI in the renal injury group and non-renal injury group were significantly higher than those in the control group,and those in the renal injury group were higher than the non-renal injury group,the differences were statistically significant(P<0.05).The levels of RBP,mAlb,NAGL and Netrin-1 in the severe asphyxia subgroup of renal injury group were significantly higher than those in the mild asphyxia subgroup,the differences were statistically significant(P<0.05);the Vs and Vd in the severe asphyxia subgroup of the renal injury group were significantly lower than those in the mild asphyxia subgroup,while RI and PI were significantly higher than those in the mild asphyxia subgroup,the differences were statistically significant(P<0.05).Conclusion The incorporation of urinary RBP and mAlb and other laboratory indicators into the serum detection index of asphyxiated neonates is helpful to improve the diagnostic accuracy and worthy of clinical popularization and application.