功能成像技术对乳腺癌新辅助化疗后疗效评估的研究进展

Advances in functional imaging techniques for evaluating the efficacy of neoadjuvant chemotherapy for breast cancer

乳腺癌是女性最常见的恶性肿瘤,死亡率更是高居不下。乳腺癌患者的生存率与其所处的肿瘤分期息息相关,新辅助化疗因其能降低乳腺癌的分期、缩小病变体积,使其达到手术或保乳的目的,越来越多应用于肿瘤的术前治疗。能反映病灶微观变化的功能成像技术可以优先于肿瘤的形态学变化,通过反映肿瘤血管系统和代谢的变化从而及时评估乳腺癌患者对于新辅助化疗反应的敏感性,为临床治疗方案的调整提供有效帮助。因此本文对于功能成像技术在新辅助化疗后乳腺癌化疗反应的优缺点及其前景进行综述。

Breast cancer is the most common malignant tumor in women, and the mortality rate is even higher. The survival rate of breast cancer patients is closely related to the tumor stage. Neoadjuvant chemotherapy is suitable for preoperative treatment of tumors. Because it can reduce the stage of breast cancer, reduce the volume of lesions, and achieve the purpose of surgery or breast conserving. Functional imaging techniques that reflect microscopic changes in the lesion can prioritize the morphological changes of the tumor. It can reflect the sensitivity of the breast cancer patient to neoadjuvant chemotherapy response by reflecting changes in the tumor vasculature and metabolism. It provides effective adjustment for clinical treatment options. This paper reviews the advantages and disadvantages of the functional imaging technique in the chemotherapy response of breast cancer after neoadjuvant chemotherapy.