期刊文献+

骨髓源性抑制细胞与肿瘤相关研究进展 被引量:4

下载PDF
导出
摘要 肿瘤是危害人类健康的重大疾病,其侵犯、转移及治疗后复发是导致患者死亡的主要原因[1]。机体的免疫系统具有识别和消灭肿瘤细胞的功能,但肿瘤细胞能够通过免疫逃逸和免疫抑制机制躲避机体的免疫反应[2]。骨髓源性抑制细胞(myeloid derived suppressor cells,MDSCs)是近年来的研究热点,与肿瘤发生发展密切相关,有抑制肿瘤免疫作用[3]。本文就MDSCs在肿瘤中的研究做一综述。
出处 《中国小儿血液与肿瘤杂志》 CAS 2019年第3期162-165,共4页 Journal of China Pediatric Blood and Cancer
  • 相关文献

参考文献3

二级参考文献18

  • 1Almand B,Clark J I,Nikitina E,et al. Increased production of immature myeloid eells in cancer patients:a meehanism of im- munosuppression in eaneer[J]. J Immunol,2001,166(1) :678- 689.
  • 2Clark C E,Hingorani S R,Mick R,et al. Dynamics of the im- mune reaction to pancreatic eaneer from inception to invasion [J]. Cancer Res, 2007,67(19) ; 9518-9527.
  • 3Diaz-Montero C M, Salem M L, Nishimura M I, et al. In- creased circulating myeloid-derived suppressor cells eorrelate with clinical caneer stage,metastatie tumor burden,and doxo- rubiein-eyelophosphamide ehemotherapy[J]. Cancer Immunol Immun,2009,58(1) :49-59.
  • 4Gabitass R F,Annels N E, Stoeken D D,et al. Elevated mye- loid-derived suppressor eells in pancreatic, esophageal and gastric cancer are an independent prognostic faetor and are as- soeiated with signifieant elevation of the Tb2 eytokine inter- leukin-13[J]. Cancer Immunol Imrnun, 2011,60 (10) : 1419- 1430.
  • 5Morales J K,Kmieeiak M,Knutson K L,et al. GM-CSF is one of the main breast tumor-derived soluble factors involved in the differentiation of CDllb-Grl-bone marrow progenitor cells into myeloid-derived suppressor cells[J]. Breast Cancer Res Tr,2010,123(1) :39-49.
  • 6Mundy-Bosse B L,Young G S,Bauer T,et al. Distinct myeloid suppressor cell subsets correlate with plasma IL-6 and IL-10 and reduced interferon-alpha signaling in CD4 (+)T cellsfrom patients with GI malignancy[J]. Cancer Immunol Im- mun,2011,60(9) :1260-1279.
  • 7Nagaraj S, Youn J I, Weber H, et al. Anti-inflammatory triter- penoid blocks immune suppressive function of MDSCs and im- proves immune response in cancer[J]. Clin Cancer Res,2010, 16(6) : 1812-1823.
  • 8Pauleau A L, Rutschman R, Lang R, eta]. Enhancer-mediated control of macrophage-speeific arginase I expression[J].J Im- munol, 2004,172 (12) : 7565-7573.
  • 9Poschke I, Mougiakakos D, Hansson J, et al. Immature immu- nosuppressive CD14+ HLA-DR /low cells in melanoma pa- tients are Stat3hi and overexpress CD80, CD83, and DC-slgn [J].Cancer Res,2010,70(11) :4335-4345.
  • 10Raychaudhuri B, Rayman P, Ireland J, et aL Myeloid-derived suppressor cell accumulation and function in patients with newly diagnosed glioblastoma[J]. Neuro Oncol, 2011,13(6) : 591-599.

共引文献9

同被引文献42

引证文献4

二级引证文献5

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部