头颈部CTA联合全脑CT灌注一站式扫描中时间间隔对灌注参数的影响

Impact of time interval on perfusion parameters in head and neck CTA combined with whole brain CT perfusion one-stop scanning

目的探讨头颈部CTA联合全脑CT灌注(CTP)一站式扫描中,时间间隔对灌注参数的影响。方法回顾性分析60例急性脑缺血症状患者的标准脑CTP图像(标准组),于颅脑CTP图像中将动脉峰值期前后各1组扫描数据剔除,使得其前后间隔时间增加至4.5 s,模拟头颈部CTA联合全脑CTP一站式扫描(模拟组)。计算标准组与模拟组灌注参数[脑血流量(CBF)、脑血容量(CBV)、平均通过时间(MTT)]绝对百分比误差值,并分析脑灰质左侧与右侧、白质左侧与右侧灌注参数比值(rCBF、rCBV、rMTT)的相关性。结果基底核层面CBF、CBV、MTT的绝对百分比误差值均值均< 10%。灰质左侧与右侧rCBF(r=0.988,P<0.001)、rCBV(r=0.963,P<0.001)、rMTT(r=0.983,P<0.001)均呈正相关,白质左侧与右侧rCBF(r=0.980,P<0.001)、rCBV(r=0.957,P<0.001)、rMTT(r=0.986,P<0.001)均呈正相关。结论头颈部CTA联合全脑CTP一站式扫描中时间间隔对灌注参数的影响较小。

Objective To explore the impact of time interval on perfusion parameters in head-neck CTA combined with one-stop scanning whole brain CT perfusion (CTP).Methods Standard brain CTP data of 60 patients with acute cerebral ischemic stroke were analyzed retrospectively (standard group).On the brain CTP images of standard group,one group of scanning data were removed before and after the peak period of the artery,and the interval between the anterior and posterior intervals increased to 4.5 s.Head and neck CTA combined with whole brain CTP one-stop scanning was simulated (simulation group).The mean absolute percentage error of perfusion parameters (cerebral blood flow [CBF],cerebral blood volume [CBV] and mean transit time [MTT]) between the standard group and the simulated group was calculated,and the correlation of perfusion parameter ratio (rCBF,rCBV,rMTT) between right and left gray matter,right and left white matter were analyzed.Results The absolute percentage errors of basal nucleus CBF,CBV and MTT were all less than 10%.There was positive correlation of gray matter left and right rCBF (r=0.988,P<0.001),rCBV (r=0.963,P<0.001) and rMTT (r=0.983,P<0.001),also of white matter left and right rCBF (r=0.980,P<0.001),rCBV (r=0.957,P<0.001) and rMTT (r=0.986,P<0.001).Conclusion The time interval between head-neck CTA combined with one-stop scanning whole brain CTP has little impact on perfusion parameters.