重组牛碱性成纤维细胞生长因子滴眼液与羟糖苷滴眼液治疗年龄相关性白内障患者术后干眼症的效果比较

Efficacy comparison of Recombinant Bovine Basic Fibroblast Growth Factor Eye Drops and Hydroxycarboside Eye Drops in the treatment of dry eye after age-related cataract operation

目的比较重组牛碱性成纤维细胞生长因子(rb-bFGF)滴眼液与羟糖苷滴眼液治疗年龄相关性白内障(ARC)患者术后干眼症的效果。方法选择2015年1月~2018年6月在安徽省铜陵市人民医院接受白内障超声乳化手术治疗的ARC患者89例进行观察。根据随机数字表法将患者分成观察组(45例)和对照组(44例)。在常规用药的基础上,对照组术后给予羟糖苷滴眼液治疗,观察组术后给予rb-bFGF滴眼液治疗,3个月后比较两组疗效、炎性因子、临床指标及不良反应发生情况。结果观察组总有效率高于对照组(P <0.05)。治疗后两组白细胞介素-1β(IL-1β)和肿瘤坏死因子-α(TNF-α)水平均较治疗前明显降低,且观察组显著低于对照组,差异有统计学意义(P <0.05)。治疗后两组的泪液分泌试验(SIt)、角膜荧光素钠染色(FL)评分及干眼症状评分均较治疗前明显降低,且观察组低于对照组,差异有统计学意义(P <0.05)。治疗后两组泪膜破裂时间(BUT)长于治疗前,且观察组长于对照组,差异有统计学意义(P <0.05)。观察组不良反应发生率低于对照组(P <0.05)。结论 rbbFGF滴眼液治疗ARC患者术后干眼症的效果更好,安全性也更佳,同时能够有效改善患者的炎症状态、泪膜损伤和角膜状况,值得临床推广。

Objective To compare the efficacy of Recombinant Bovine Basic Fibroblast Growth Factor(rb-bFGF) Eye Drops and Hydroxycarboside Eye Drops in the treatment of dry eye after age-related cataract( ARC) operation.Methods Eighty-nine patients with ARC who underwent phacoemulsification in Tongling People′s Hospital from January 2015 to June 2018 were observed. Patients were divided into observation group(45 cases) and control group(44 cases) by random number table method. On the basis of routine medication, the control group was treated with Hydroxycarboside Eye Drops after operation, while the observation group was treated with rb-bFGF Eye Drops after operation.After 3 months, the efficacy, inflammatory factor, clinical indicators and adverse reactions of the two groups were compared. Results The total effective rate of the observation group was higher than that of the control group(P < 0.05). After treatment, the levels of interleukin-1β(IL-1β) and tumor necrosis factor-α(TNF-α) in the two groups were significantly lower than those before treatment, and the observation group was significantly lower than the control group, the differences were statistically significant(P < 0.05). The Schirmer I test(SIt), fluorescein corneal staining(FL) and dry eye symptom score of the two groups were significantly lower than those before treatment, and the observation group was lower than the control group, the differences were statistically significant(P < 0.05). The tear break-up time(BUT)of the two groups after treatment was longer than that before treatment, and the observation group was longer than the control group, the differences were statistically significant(P < 0.05). The incidence of adverse reactions in the observation group was lower than that in the control group(P < 0.05). Conclusion rb-bFGF Eye Drops has better efficacy and safety in the treatment of dry eye after ARC operation, and can effectively improve inflammation, tear film injury and corneal condition. It is worthy of promotion in clinic.