外周血T细胞亚群与突发性耳聋发病的关系

Relationship between peripheral blood T cell subsets and onset of sudden deafness

目的探讨外周血T细胞亚群与突发性耳聋发病及预后的关系。方法选取2016年8月~2018年8月湖北省鄂州市中心医院收治的76例突发性耳聋患者作为研究组,另选取同期进行健康检查的健康体检者60名作为对照组。研究组患者采用常规治疗,连续治疗10 d,检测并比较两组外周血T细胞亚群水平。根据疗效将研究组分为有效组(54例)和无效组(22例),根据研究组外周血T细胞亚群失衡情况,将患者分为正常组(27例)和失衡组(49例),比较两组治疗的有效率。结果与对照组比较,研究组治疗前外周血CD3^+、CD4^+及CD4^+/CD8^+明显较低,而CD8^+明显较高,差异有统计学意义(P <0.05)。研究组治疗后外周血CD4^+和CD4^+/CD8^+明显升高,CD8^+明显降低,与治疗前比较差异有统计学意义(P <0.05)。研究组治疗后外周血CD3^+、CD4^+与对照组比较差异无统计学意义(P> 0.05),而CD4^+/CD8^+明显较低,CD8^+明显较高,差异有统计学意义(P <0.05)。与有效组比较,无效组CD3^+、CD4^+及CD4^+/CD8^+明显较低,而CD8^+明显较高,差异有统计学意义(P <0.05)。正常组的治疗有效率为88.89%,明显高于失衡组的61.22%,差异有统计学意义(P <0.05)。结论突发性耳聋的发病与外周血T细胞亚群失衡存在一定关系,免疫功能障碍可能影响突发性耳聋患者的听力恢复。

Objective To investigate the relationship between peripheral blood T cell subsets and onset and prognosis of sudden deafness. Methods Seventy-six patients with sudden deafness admitted to Ezhou Central Hospital from August 2016 to August 2018 were selected as the study group. Another 60 healthy people who underwent health examination during the same period were selected as the control group. The patients in the study group received routine treatment for 10 d. The level of peripheral blood T cell subsets of the two groups was detected and compared. According to the curative effect, the study group were divided into effective group(54 cases) and ineffective group(22 cases), the level of peripheral blood T cell subsets of the two groups was compared. According to the imbalance of peripheral blood T cell subsets of the study group, the patients were divided into normal group(27 cases) and imbalance group(49 cases),the effective rate of the two groups was compared. Results Compared with the control group, CD3^+, CD4^+and CD4^+/CD8^+in peripheral blood of the study group before treatment were significantly lower, while CD8^+was significantly higher, the differences were statistically significant(P < 0.05). The peripheral blood CD4^+and CD4^+/CD8^+in the study group were significantly increased and CD8^+was significantly decreased after treatment compared with those before treatment, the differences were statistically significant(P < 0.05). Compared with the control group, there was no significant difference in CD3^+and CD4^+in peripheral blood after treatment in the study group(P > 0.05), but CD4^+/CD8^+was significantly lower and CD8^+was significantly higher in the study group(P < 0.05). Compared with the effective group,CD3^+, CD4^+and CD4^+/CD8^+in the ineffective group were significantly lower, while CD8^+was significantly higher, the differences were statistically significant(P < 0.05). The effective rate of treatment in the normal group(88.89%) was significantly higher than that in the imbalance group(61.22%)(P < 0.05). Conclusion The onset of sudden deafness is related to the imbalance of peripheral blood T cell subsets. Immune dysfunction may affect the hearing recovery of sudden deafness patients.