氨氯地平阿托伐他汀钙片治疗高血压、冠心病合并颈动脉粥样硬化患者的临床价值及安全性

Clinical Value and Safety of Amlodipine Atorvastatin Calcium Tablet in the Treatment of Hypertension,Coronary Heart Disease Complicated with Carotid Atherosclerosis

目的分析氨氯地平以及阿托伐他汀钙片治疗高血压、冠心病合并颈动脉粥样硬化患者的临床价值以及安全性。方法选取2017年1月-2018年2月收治的高血压、冠心病合并颈动脉粥样硬化患者38例作为研究对象,将其按照不同的治疗方式进行分组,一组为参照组,对其采取单一的氨氯地平进行治疗;另一组为联合组,对其采取氨氯地平联合阿托伐他汀进行治疗,每组各19例。对两组的治疗有效率、不良反应发生率以及治疗前、后的收缩压、舒张压与颈动脉粥样斑块厚度进行比较。结果联合组患者的治疗有效率高于参照组,不良反应发生率低于参照组(P<0.05);治疗前,两组患者的收缩压、舒张压与颈动脉粥样斑块厚度比较无显著差异(P>0.05),治疗后两组患者的收缩压以及舒张压均低于治疗前,颈动脉粥样斑块厚度较治疗前有显著缩小,且联合组患者的收缩压与舒张压低于参照组,颈动脉粥样斑块厚度显著缩小于参照组(P<0.05),差异显著。结论对高血压、冠心病合并颈动脉粥样硬化患者采取氨氯地平联合阿托伐他汀钙片进行治疗,可有效改善患者的血压水平,缩小颈动脉粥样斑块厚度,提高治疗效果,降低不良饭发生率,值得临床借鉴并推广。

Objective To analyze the clinical value and safety of amlodipine and Atto vastatin calcium tablets in the treatment of hypertension,coronary heart disease complicated with carotid atherosclerosis. Methods The 38 patients with hypertension and coronary heart disease complicated with carotid atherosclerosis were selected from January 2017 to February 2018 in our hospital. The patients were divided into two groups according to different treatment methods,one group was the control group,the other was the control group. It was treated with a single amlodipine. The other group was treated with amlodipine combined with Atto vastatin,19 cases in each group. The effective rate of treatment in two groups and the occurrence of adverse reactions The growth rate,systolic and diastolic blood pressure before and after treatment were compared with carotid atherosclerotic plaque thickness. Results The effective rate of treatment in the combined group was higher than that in the reference group, and the incidence of adverse reactions was lower than that in the reference group ( P < 0. 05). Before treatment,there was no significant difference in systolic blood pressure,diastolic blood pressure and carotid atherosclerotic plaque thickness between the two groups ( P > 0. 05). After treatment,systolic blood pressure and diastolic blood pressure in the two groups were lower than those before treatment. The thickness of carotid atherosclerotic plaque was significantly smaller than that before treatment,and the systolic and diastolic blood pressure in the combined group was lower than that in the reference group,and the carotid atherosclerotic plaque thickness in the combined group was significantly smaller than that in the reference group ( P < 0. 05),the difference was significant. Conclusions Amlodipine combined with Atto - vastatin calcium tablets can effectively improve the blood pressure,reduce the thickness of carotid atherosclerotic plaque and improve the therapeutic effect in patients with hypertension and coronary heart disease complicated with carotid atherosclerosis. Reducing the incidence of bad meal is worthy of clinical reference and promotion.