中西医治疗获得性免疫缺陷综合征免疫重建不良疗效评价

Therapeutic Evaluation of Chinese with Western Medicine Therapy on Poor Immune Reconstitution in Acquired Immunodeficiency Syndrome

获得性免疫缺陷综合征(Acquired immunodeficiency syndrome,AIDS)的防治现阶段仍是全球性的难题,其发病和进展过程中,人类免疫缺陷病毒(Human immunode ficiency virus,HIV)与宿主免疫系统的作用是关键,CD4^+T淋巴细胞是HIV病毒攻击的主要靶细胞,随着疾病的进展,CD4^+T淋巴细胞功能遭到破坏并进行性减少,使宿主免疫功能低下,进而出现严重的机会性感染和肿瘤等。高效抗逆转录病毒治疗(Highly active antiretroviral therapy,HAART)虽然对提高患者免疫功能有一定效果,但长期治疗后改善不明显。中医药对艾滋病免疫功能的调节作用已经得到证实。但其作用机制尚不明确,仍需进一步探索研究。

The prevention and treatment of acquired immunodeficiency syndrome(AIDS) is still a global problem. In its pathogenesis and progress,the effect of human immunodeficiency virus(HIV) and host immune system is the key,and CD4^+ T lymphocyte is the main target cell attacked by HIV. With the progress of the disease, the destruction and progressive reduction in the function of CD4^+ T lymphocyte result in the low host immune function, thus leading to the high risk of severeopportunistic infections and tumors. Although highly active antiretroviral therapy(HAART) has certain effect on improving the immune function of patients, the improvement is not obvious after long-term treatment. The regulation of Chinese medicine on the immune function of AIDS has been confirmed, but its mechanism is still unclear, which needs further research.