养胃颗粒治疗慢性萎缩性胃炎临床研究

Clinical Study on Yangwei Granules for Chronic Atrophic Gastritis

目的:观察养胃颗粒治疗慢性萎缩性胃炎的临床疗效。方法:将因慢性萎缩性胃炎进行治疗并且符合纳入标准的99例患者采用随机数字表法分为对照组49例和观察组50例,对照组常规给予质子泵抑制剂(PPI)雷贝拉唑与阿莫西林、克拉霉素抗酸抑菌治疗,观察组在对照组基础上加用养胃颗粒联合治疗。记录2组治疗后幽门螺杆菌(Hp)根除情况与胃镜下黏膜炎症改善情况;观察治疗后2组总体疗效以及不良反应发生率。结果:治疗后,胃黏膜炎症总有效率观察组为90.0%,对照组为75.5%,2组比较,差异有统计学意义(P <0.05)。治疗后观察组Hp清除率为94.0%,对照组为71.4%,差异有统计学意义(P <0.05)。治疗后,观察组临床总有效率94.0%,对照组为87.8%,2组比较,差异有统计学意义(P <0.05)。观察组不良反应总发生率为3.8%,对照组为14.3%,2组比较,差异有统计学意义(P <0.05)。结论:在传统质子泵抑制剂雷贝拉唑以及抗生素抗酸抑菌治疗基础上给予养胃颗粒联合治疗慢性萎缩性胃炎,可更加有效降低胃黏膜炎症,减少Hp感染,更有效保护患者胃黏膜功能,增加治疗有效率,同时减少不良反应,表明中西医联合治疗比单独PPI联合抗Hp药物治疗更加安全有效。

Objective:To observe the clinical effect of Yangwei granules for chronic atrophic gastritis. Methods:99 cases of patient with chronic atrophic gastritis who received treatment and met the inclusive criteria were divided into two groups randomly, 49 cases in the control group and 50 cases in the observation group.The control groups routinely received such proton pump inhibitor(PPI) as rebeprazole, amoxicillin and clarithromycin for antiacid and bacteriostatic treatment, the observation group additionally received Yangwei granules. Recorded the eradication of helicobacter pylori(Hp) and improvements of gastric mucosa inflammation under gastroscope in both groups after treatment,and observed the overall clinical effect and incidence of adverse reactions in both groups after treatment. Results: After treatment, the total effective rate of gastric mucosa inflammation was 90.0% in the observation group and 75.5% in the control group, difference being significant(P <0.05). After treatment,the eradication rate of Hp was 94.0% in the observation group and 71.4% in the control group,difference being significant(P < 0.05). After treatment,the total clinical effective rate was 94.0% in the observation group and 87.8% in the control group, difference being significant(P < 0.05). The incidence of adverse reactions was 3.8% in the observation group and 14.3% in the control group, difference being significant(P < 0.05). Conclusion: The combined application of Yangwei granules based on such conventional PPI as rebeprazole and antibiotics in antiacid and bacteriostatic treatment for chronic atrophic gastritis can more effectively decrease gastric mucosa inflammation,reduce Hp infection,protect the gastric mucosa functions of patients and decrease adverse reactions. Therefore, it indicates that integrated Chinese and western medicine therapy is safer and more effective than the simple application of PPI combined with anti-Hp medicine.