外泌体源性miRNA在肿瘤发生发展中作用的研究进展

Research progress on the role of exosomal miRNA in the occurrence and development of tumors

外泌体作为细胞间信息交流的重要媒介,可携带蛋白质、脂质、核酸等多种信息物质到受体细胞中,使受体细胞产生不同的生化反应进而调节各项生命活动。近年来大量研究表明,外泌体源性miRNA广泛参与包括肿瘤在内的多种疾病的发生发展。为了更好地了解外泌体源性miRNA对肿瘤发生发展的影响,该文综述了外泌体源性miRNA在肿瘤血管生成、上皮-间质转化、免疫调节、转移前微环境、耐药等方面的作用。

Exosomes, the important cell-cell communication players, can carry a variety of signal molecules, such as proteins, lipids, and nucleic acids, into the recipient cells, allowing these cells to produce different biochemical reactions and regulate various life activities. In recent years, accumulating evidence has demonstrated that exosomal miRNAs participate extensively in the occurrence and development of multiple diseases, including tumors. In this review, we summarized the role of exosomal miRNAs in tumor angiogenesis, epithelial-mesenchymal transition,immunoregulation, pre-metastatic niche, and drug resistance to better understand the effects of exosomal miRNAs on the occurrence and development of tumors.