生物力学因子YAP/TAZ与骨代谢的关系

Relationship between the biomechanical factor YAP/TAZ and bone metabolism

运动等机械负荷在骨骼内由局部信号转化为生化信号参与调控骨代谢进程。机械指令借助可感知应力刺激的转录共激活因子YAP/TAZ得以在细胞核中发挥效用,这一发现揭示了力学传导驱动生理、病理状态下的细胞行为学原理。近期研究证实,YAP/TAZ与Wnt/β-连环蛋白(β-catenin)、Notch等骨代谢通路之间存在串话现象,并影响多种骨组织细胞的分化及功能。深入探讨YAP/TAZ在骨代谢过程中的机制作用,对于骨组织疾病的预防和治疗具有重要意义。该文从YAP/TAZ对机械应力的感知作用入手,分析YAP/TAZ与Wnt/β-连环蛋白、Notch通路的相关性,并对其在骨组织细胞领域的研究进行概述。

Mechanical loads, such as exercise, are transformed from local signals into biochemical signals to participate in the bone metabolism. There is extensive evidence that mechanical cues can act on the nucleus by transcriptional coactivator YAP/TAZ, which also act as the mechanical sensor. This finding reveals the mechanism about pathophysiological cellular behavior under the mechanical force. Recent studies have confirmed that there is a crosstalk among YAP/TAZ, Wnt/β-catenin, Notch and other bone metabolic pathways. And they will affect the differentiation and function of various bone tissue cells. Therefore, it is important that studying the roles of YAP/TAZ in bone metabolism and it is very meaningful to fully understand the pathogenesis of bone diseases. This review, starting with YAP/TAZ mechanical sensing and analysing the correlation among YAP/TAZ, Wnt/β-catenin and Notch pathways, summarizes the related research in the field of bone tissue cells.