肾功能水平对老年直立性低血压患者脑缺血症状发生的影响

Effect of renal function on cerebral ischemia symptoms in elderly patients with orthostatic hypotension

目的探讨肾功能水平对老年直立性低血压(OHP)患者脑缺血症状发生的影响。方法采用回顾性研究方法,收集我院75例直立性低血压患者脑缺血症状、卧立位血压、Ccr等临床资料,相关资料进行统计学分析。结果 Ccr与OHP有显著相关性;随着Ccr下降,有症状直立性低血压发病风险有增加趋势,Ccr对OHP的最佳预测节点为50.52 ml/min;进一步分析表明Ccr与卧立位收缩压差值(r=0.977,P=0.000)及卧立位舒张压差值(r=0.264,P=0.022)呈正相关。结论 Ccr与老年直立性低血压患者脑缺血相关症状的发生显著相关,其机制可能与卧立位收缩压差值相关。

Objective To investigate the effect of renal function on cerebral ischemia symptoms in elderly patients with orthostatic hypotension(OHP). Methods The clinical data of cerebral ischemia symptoms, in supine and standing positions blood pressure, Ccr and other clinical data of 75 patients with orthostatic hypotension in our hospital were collected by retrospective research method, and the relevant data were statistically analyzed. Results Ccr is significantly correlated with OHP. With the decrease of Ccr, the incidence risk of symptomatic orthostatic hypotension tends to increase. The best prediction node of Ccr for OHP was 50.52 ml/min. Further analysis shows that Ccr is positively correlated with in supine and standing positions systolic blood pressure difference (r=0.977, P=0.000) and in supine and standing positions diastolic blood pressure difference (r=0.264, P=0.022). Conclusion Ccr is significantly related to the occurrence of cerebral ischemia-related symptoms in elderly patients with orthostatic hypotension, and its mechanism may be related to the difference of in supine and standing positions systolic blood pressure.