间充质干细胞移植治疗新生儿支气管肺发育不良:机遇与挑战

Mesenchymal stem cell transplantation in the treatment of bronchopulmonary dysplasia:opportunities and challenges

支气管肺发育不良(BPD)是新生儿尤其是早产儿最常见的慢性肺部疾病,是导致早产儿预后不良的重要原因,目前临床使用的治疗手段仍然难以很好改善其预后.近年来,实验及临床研究发现间充质干细胞移植对BPD有一定疗效,可能成为未来最有希望的治疗手段.该文就间充质干细胞的特点、间充质干细胞移植治疗BPD的可能机制及临床试验的安全性和可行性,以及进一步相关临床研究面临的挑战进行阐述.

Bronchopulmonary dysplasia (BPD) is one of the most common chronic lung diseases in neonates especially in preterm infants. It is also the main reason leading to a poor prognosis. The prognosis of the neonates with BPD is unsatisfactory with current treatment strategies. Recent clinical trails have found that mesenchymal stem cell (MSC) transplantation might be effective and promising for treatment of BPD in neonates. This article outlines the characteristics of MSC and the potential mechanisms of MSC transplantation for BPD in vivo, and the safety and feasibility of MSC transplantation in BPD neonates, as well as the challenges in clinical trials on MSC transplantation for treatment of BPD.