摘要
应用基因组学、转录组学、蛋白质组学、代谢组学数据联合系统生物学分析对胰腺癌进行分子分型,极大地丰富了基于形态学的传统组织病理学分型方法。分子分型体现出对肿瘤本质认知的深入,是开展靶向治疗及精准医学模式的必要基础,具有广阔的应用前景。笔者就胰腺癌分子分型的研究现状与进展进行阐述,探讨不同分型方法的临床意义。
Rational molecular subtyping of pancreatic cancer based on genome, transcriptome, proteomics and metabolomics data, in combination with systematic biological analysis, have greatly enriched the traditional histopathological typing methods based on morphology. The introduction of molecular subtyping reflects the progress in deep understanding of the essence of tumorigenesis of pancreatic cancer, providing a necessary foundation for the development of molecular targeted therapy and implementation of precision medicine. Therefore, molecular subtyping of pancreatic cancer has broad application prospects. The current article reviews the current research status and recent progress of molecular subtyping of pancreatic cancer, and discusses the clinical significance of different subtyping methods.
作者
杨尹默
张正奎
田孝东
Yang Yinmo;Zhang Zhengkui;Tian Xiaodong(Department of General Surgery, Peking University First Hospital, Beijing 100034, China)
出处
《中华消化外科杂志》
CAS
CSCD
北大核心
2019年第7期616-620,共5页
Chinese Journal of Digestive Surgery
基金
国家自然科学基金(81672353、81871954)
首都临床特色应用研究项目(Z161100000516038).
关键词
胰腺肿瘤
胰腺癌
分子分型
分子靶向治疗
进展
Pancreatic neoplasms
Pancreatic can-cer
Molecular subtypes
Molecular targeted therapy
Progress
