胰腺癌综合治疗新进展

New advances in comprehensive treatment for pancreatic cancer

胰腺癌是一种恶性程度极高、预后极差的消化系统肿瘤。近30~40年来,尽管外科手术技术进展迅速,手术切除率有所提高,围术期病死率及并发症发生率显著下降,但临床疗效的改善仍差强人意。随着对胰腺癌生物学行为认知的不断深入,其治疗模式已从单纯依靠外科治疗逐步转为以多学科联合为基础的包括手术、化疗和放疗等综合诊断与治疗。综合诊断与治疗的理念与价值逐渐得到了临床医师的认可,也为胰腺癌的治疗带来新的发展机遇。

Pancreatic cancer is a highly digestive system malignancy with an extremely poor prognosis. Although the rapid improvements of surgical technique have resulted in the increase in the resection rate and the significant decline in peri-operative morbidity and mortality, the prognosis of pancreatic cancer remains far from satisfying. As the understanding of tumor biological behavior deepens, the treatment strategy of pancreatic cancer has been changed from "surgery first" to multidisciplinary team (MDT) based comprehensive management including surgery, chemotherapy, radiotherapy and others. In the past decade, MDT modality has been employed widely in high volume pancreatic center and has improved the management of pancreatic cancer. Here, the authors reviewed the recent advances in systematic treatment for pancreatic cancer, with an aim to provide new horizons of optimal management.