扩散张量成像FA值在新生儿HIE早期诊断及预后判断中的价值

Predominance and prognostic value in early diagnosis of neonatal HIE by 3.0T diffusion tensor imaging FA

目的分析扩散张量成像(DTI)的各向异性分数(FA)值在新生儿缺氧缺血性脑病(HIE)早期诊断中的临床应用价值。方法选取该院2015年5月至2018年5月收治的45例HIE新生儿作为观察组,按照病情轻重分为轻度组18例,中度组12例,重度组15例,另选择同期该院体检健康新生儿15例作为对照组,所有研究对象均采用3.0T超导型MRI仪行颅脑MRI常规序列及DTI序列扫描。测量并比较各组研究对象颅脑各个感兴趣区内的FA值。结果观察组额叶深部髓质、顶枕叶深部髓质、小脑半球、脑干、内囊后肢、豆状核区、丘脑的平均FA值低于对照组,差异均有统计学意义(P<0.05)。且上述感兴趣区平均FA值在对照组、轻度组、中度组、重度组中依次降低,两两比较,差异均有统计学意义(P<0.05)。结论采用DTI的FA值可早期诊断并评估新生儿HIE的预后。

Objective To explore and analyze the clinical application value of diffusion tensor imaging (DTI) anisotropic fraction (FA) in the early diagnosis of neonatal hypoxic ischemic encephalopathy (HIE).Methods A total of 45 patients of neonatal HIE in Hunan Provincial Maternal and Child Health Care Hospital from May 2015 to May 2018 were selected into observation group,then divided into mild group (18 cases),moderate group (12 cases) and severe group (15 cases) according to the state of illness,meanwhile 15 healthy neonatals were recruited into control group.All the objects were given regular 3.0T magnetic resonance cerebral MRI sequence and sequence of DTI scan.FA value was measured in all interest areas of the brain in the mild group,moderate group,severe group and control group.Results Compared with the control group,the average FA values of deep medulla of the frontal lobe,deep medulla of the parietal occipital lobe,cerebellar hemisphere,brainstem,posterior ramus of the internal capsule,pacliform nucleus and thalamus of the observation group were all lower,with statistically significant differences (P<0.05).The average FA values of the interest areas above decreased gradually in control group,mild group,moderate group and severe group,with statistically significant differences (P<0.05).Conclusion The FA value of DIT can be used as an objective basis for early diagnosis and assessment of prognosis of neonatal HIE.