南京地区18759例住院新生儿TORCH检测结果分析

Analysis of TORCH infection of 18 759 hospitalized neonates in Nanjing

目的 了解南京地区住院新生儿TORCH感染情况,为相关疾病诊疗提供参考依据。方法 采用化学发光免疫分析法对该院2014-2017年18 759例住院新生儿进行弓形虫(TOX)、风疹病毒(RV)、巨细胞病毒(CMV)、单纯疱疹病毒(HSVⅠ+Ⅱ)IgM进行血清学检测。结果 新生儿TORCH-IgM总阳性率为 0.51 %,CMV-IgM阳性率最高(0.23%),其次为HSV-IgM(Ⅰ+Ⅱ) 0.17%,RV-IgM 0.10%,TOX-IgM 0.02 %,差异有统计学意义( P < 0.05 )。RV-IgM阳性患儿中,男性新生儿阳性率为0.14%,女性新生儿阳性率为 0.05 %,差异有统计学意义( P <0.05);TORCH-IgM阳性患儿中,早产儿39例,非早产儿56例,早产患儿少于非早产患儿,且早产患儿中HSV感染人数最多;CMV-IgM阳性率呈现逐年上升的趋势, 2014- 2017 年CMV-IgM阳性率分别为0.15%、0.19%、0.24%、0.38%。结论 南京地区住院新生儿TORCH-IgM阳性率较低,以CMV感染为主,但CMV-IgM阳性率有逐年上升的趋势,防治形势仍然不可轻视。

Objective To understand the TORCH infection status of hospitalized neonates in Nanjing area,and to provide reference for the diagnosis and treatment of related diseases. Methods 18 759 cases of hospitalized neonates were tested for antibodies by chemiluminescence immunoassay from 2014 to 2017.Four pathogens of TORCH were detected:Toxoplasma gondii (TOX),rubella virus (RV),cytomegalovirus (CMV) and human herpes virus (HSVⅠ+Ⅱ). Results The total positive rate of TORCH-IgM was 0.51%,CMV-IgM 0.23%,HSV-IgM(Ⅰ+Ⅱ) 0.17%,RV-IgM 0.10%,TOX-IgM 0.02% respectively,the difference was statistically significant ( P <0.05).Among the positive neonates of RV-IgM,the positive rate of male neonates was 0.14 %,and that of female neonates was 0.05%,the difference was statistically significant ( P <0.05).Among the neonates infected by TORCH,the number of premature infants and non-premature infants were 39 and 56,premature infants were less than non-premature infants.And the number of neonates with HSV infection was the highest in premature infants.The positive rate of CMV-IgM showed a trend of rising year by year,and the positive rate of CMV-IgM was 0.15%,0.19%,0.24% and 0.38% respectively from 2014 to 2017. Conclusion The positive rate of TORCH-IgM in hospitalized neonates in Nanjing area is low.CMV is the primary pathogen and the positive rate of CMV-IgM has a trend of rising year by year.So the prevention and treatment situation should not be underestimated.