Suzuki反应中催化体系的研究进展

Research Progress of Catalytic System for Suzuki Reaction

随着过渡金属催化的交叉偶联反应的出现,有机合成化学在20世纪的最后25年得到了快速的发展,并且这些反应的重要性被普遍认可.其中,Suzuki偶联反应因其多功能性、兼容性和对包括材料科学和药物合成在内的多种学科的关键贡献,而占据了更加特殊的地位.尽管到2010年为止Suzuki反应已取得重大进展,但随着可持续和绿色化学发展的需求,Suzuki反应的催化体系仍待进一步优化提高.这里概述的催化剂为C-C键的构建提供了方便和绿色的合成途径.在这篇综述中,我们总结了科研工作者对于Suzuki反应在改进催化剂制备策略、优化催化反应条件、提高催化剂重复利用性能和降低催化剂成本方面做的一系列研究.

With the emergence of cross-coupling reactions catalysed by transition metals, organic synthetic chemistry developed rapidly in the last 25 years of the 20th century, and the importance of Suzuki reaction was generally recognized. The Suzuki reaction is a special place because of its versatility, compatibility and key contributions to many disciplines, including materials science and drug synthesis. Although the Suzuki reaction has made great progress until 2010, the system still needs to be further optimized and improved due to the sustainable and green che-mistry development. The catalysts outlined here allow convenient and green synthetic pathways specifically for the construction of C-C bonds. In this review, we have summarized the recent developments on Suzuki reaction study in catalyst preparation strategy improvement, reaction condition optimization, catalyst reusing performance enhancements and catalyst cost reducing.