硅酮敷料治疗创伤性传染性湿疹样皮炎的疗效及安全性分析

Analysis on efficacy and safety of silicone dressing in treating traumatic infectious eczematous dermatitis

目的探讨硅酮敷料治疗创伤性传染性湿疹样皮炎的疗效及安全性。方法将62例创伤性传染性湿疹样皮炎患者分为治疗组与对照组,每组31例。所有患者均给予抗过敏及有效处理局部伤口,在此基础上治疗组连续使用硅酮敷料治疗3个月,对照组使用夫西地酸乳膏治疗4周。4周后,比较治疗前后两组患者的疗效、皮损恢复时间,治疗过程中的不良反应;3个月后,观察创面瘢痕形成情况,采用患者和观察者瘢痕评估量表进行评价。结果治疗后,两组患者湿疹面积及严重程度指数(EASI)评分较治疗前均明显降低(P<0.01),治疗组EASI评分低于对照组(P<0.05)。治疗组患者治疗传染性湿疹样皮炎总有效率(96.77%)高于对照组(90.32%),但差异无统计学意义(P>0.05),皮损愈合时间短于对照组(P<0.05)。治疗组患者和观察者瘢痕评估量表评分低于对照组(P<0.05),两组均未见明显不良反应。结论硅酮敷料治疗创伤性传染性湿疹样皮炎疗效确切,能缩短皮损愈合时间,改善皮损预后效果,不良反应少。

Objective To investigate the efficacy and safety of silicone dressing in treating traumatic infectious eczema-like dermatitis.Methods Sixty-two patients with traumatic infectious eczematous dermatitis were divided into the treatment group and the control group with 31 cases in each group.All cases were given anti-allergy and effective treatment of local wound.On this basis,the treatment group was treated by silicone dressing for 3 months,while the control group was treated Fusidic Acid Cream for 4 weeks.Then the efficacy,recovery time of skin lesions and adverse reactions during treatment process after 4 weeks of treatment were compared between the two groups.The wound surface scar formation situation was observed after 3 months and Patient and Observer Scar Assessment Scale(POSAS)was used to conduct the evaluation.Results The eczema area and severity index(EASI)scores after treatment in the two groups significantly decreased compared with before treatment(P<0.01),the EASI score in the treatment group was lower than that in the control group(P<0.05);the total effective rate in the treatment group was 96.77%,which was higher than 90.32%in the control group,but the difference was not statistically significant(P>0.05);the recovery time of skin lesion was shorter than that in the control group(P<0.05).The POSAS score of the treatment group was lower than that of the control group,and the difference was statistically significant(P<0.05).No obvious adverse reactions were found in both groups.Conclusion Silicone dressing is definitely effective to treat traumatic infectious eczema-like dermatitis,which shortens the healing time of skin lesion and improve the progrnsis with less adverse reactions.It is worthy of clinical promotion.