MFG-E8参与细胞凋亡机制及在慢性阻塞性肺疾病中作用的研究进展

Research advance on MFG-E8 involving in apoptosis mechanism and its role in chronic obstructive pulmonary disease

在健康个体中,凋亡细胞通过包括巨噬细胞、树突状细胞在内的专业吞噬细胞迅速有效地去除,这一过程称为凋亡细胞清除。通常情况下,细胞凋亡过程受机体内严格调控,但当细胞凋亡调控失衡时,即可引起细胞过度增殖或过度凋亡。现已有越来越充足的证据支持慢性阻塞性肺疾病(COPD)细胞凋亡机制,乳脂球表皮生长因子8(MFG-E8)可作为桥梁因子参与细胞凋亡过程。MFG-E8有助于清除凋亡细胞并抑制炎性反应,从而参与维持多种生理系统的平衡。该文就MFG-E8参与细胞凋亡的作用机制研究及近年来其在COPD中作用的研究进展做一综述。

In healthy individuals,apoptotic cells are rapidly and efficiently removed by specialized phagocytic cells including macrophages and dendritic cells,this process is called as apoptotic cell clearance.Under normal conditions,the process of cellular apoptosis is strictly regulated in the body,but when the regulation of apoptosis is imbalanced,it can cause the cell excessive proliferation or excessive apoptosis.There are more and more sufficient evidences to support the mechanism of apoptosis in chronic obstructive pulmonary disease(COPD),and milk fat globule-EGF factor Ⅷ(MFG-E8)can serve as a bridge factor involving in the process of cellular apoptosis.MFG-E8 helps to clear apoptotic cells and inhibit inflammation reaction,thereby participates in and maintains the balance of multiple physiological systems.The research advances on the mechanism of MFG-E8 involving in cellular apoptosis and its role in COPD during recent years are reviewed.