南昌市某高校退休职工高尿酸血症调查及其影响因素分析

Prevalence of Hyperuricemia and Its Influencing Factors among Retired Staff in a University of Nanchang

目的 了解南昌市某高校退休职工高尿酸血症(HUA)的检出率及其影响因素,为预防控制HUA提供参考依据。方法 收集2017年1230例南昌市某高校退休职工的体检资料,分析HUA的检出率,用多因素Logistic回归分析HUA与性别、年龄、血糖、血脂、肝功能和肾功能的关系。结果 1230例退休职工的SUA平均水平为340.90(284.08~401.50)μmol·L^-1,男性为379.10(327.45~438.25)μmol·L^-1,女性为309.90(264.10~356.40)μmol·L^-1,男性SUA水平显著高于女性(U=97 922.00,P <0.001);女性SUA水平随年龄增加而逐渐升高(H=25.001,P <0.001)。HUA总检出率为19.19%(236/1230),男性高于女性(31.28%比9.31%,χ^2=94.82,P <0.001)且各年龄组HUA检出率女性均低于男性(P<0.001),男性和女性HUA检出率均随年龄增加而上升(χ^2 男=4.89,P 男=0.027;χ^2 女=7.00,P 女=0.008)。HUA组(n=994)的年龄、空腹血糖(FPG)、三酰甘油(TG)、谷丙转氨酶(ALT)、γ-谷酰胺转酞酶(GGT)、谷草转氨酶(AST)、血尿素氮(BUN)和血肌酐(SCr)水平均高于尿酸正常组(n=236)(P<0.01),而高密度脂蛋白胆固醇(HDL-C)低于尿酸正常组(P<0.01);Logistic多因素回归分析显示,男性、年龄、低HDL-C、高GGT和高BCr是HUA的主要危险因素(P<0.05)。结论 南昌市某高校退休职工HUA的检出率较高,男性、年龄、低HDL-C、高GGT和高BCr是HUA的独立危险因素。

Objective To explore the detection rate of hyperuricemia(HUA) and its influencing factors among retired staff in a university in Nanchang,and to provide reference for the prevention and control of HUA.Methods The physical examination data(2017) of 1230 retirees from a university in Nanchang were collected to investigate the detection rate of HUA.Multivariate logistic regression analysis was used to analyze the relationships of HUA to gender,age,blood glucose level,blood lipid level,liver function and renal function.Results The average serum uric acid(SUA) level in the 1230 retirees was 340.90 mol·L^-1 (range 284.08 mol·L^-1 to 401.50 mol·L^-1),and that in males(379.10 mol·L^-1 ,range 327.45 mol·L^-1 to 438.25 mol·L^-1) was higher than that in females(309.90 mol·L^-1 ,range 264.10 mol·L^-1 to 356.40 mol·L^-1)(U= 97 922.00 ,P<0.001).Furthermore,the level of SUA increased with age in females(H= 25.001 ,P<0.001).The overall detection rate of HUA was 19.19%(236/1230),and the incidence of HUA in males was higher than that in females(31.28% vs 9.31%,χ^2=94.82,P<0.001).The detection rate of HUA increased with age in both males(χ^2=4.89,P=0.027) and females(χ^2= 7.00 ,P= 0.008).Compared with normal SUA group(n=236),the age and levels of fasting blood-glucose,triglyceride,alanine aminotransferase,γ-glutamine transferase(GGT),aspartate aminotransferase,blood urea nitrogen and serum creatinine(SCr) increased,but high-density lipoprotein cholesterol(HDL-C) concentrations decreased in HUA group(n=994)(P<0.01).The male,age,low HDL-C,high GGT and high BCr were the main risk factors for HUA(P<0.05).Conclusion The prevalence of HUA is high among retired staff in a university in Nanchang.The male,age,low HDL-C,high GGT and high BCr are independent risk factors for HUA.