米非司酮联合甲氨蝶呤治疗异位妊娠的有效性分析

Analysis of the efficacy of mifepristone combined with methotrexate in the treatment of ectopic pregnancy

目的探讨米非司酮联合甲氨蝶呤治疗异位妊娠的有效性分析。方法选取本院2016年5月至2018年1月76例异位妊娠患者,采用抽签方式分为两组,即观察组与对照组,各38例。观察组行米非司酮+甲氨蝶呤治疗,对照组采用甲氨蝶呤治疗,对比治疗效果。结果治疗后,两组患者症状均得到显著改善,且观察组附件包块直径(1.25±0.81)cm、β-HCG(140.25±52.56)U/L均低于对照组(1.78±0.52)cm、(290.36±56.94)U/L(P<0.05);观察组患者并发症发生率为13.16%,与对照组34.21%比较明显较低(P<0.05),且观察组患者β-HCG恢复至正常时间(21.25±4.13)d,与对照组(26.89±4.31)d比较明显缩短(P<0.05)。结论米非司酮联合甲氨蝶呤治疗异位妊娠效果显著,值得推广。

Objective To investigate the efficacy of mifepristone combined with methotrexate in the treatment of ectopic pregnancy. Methods 76 patients with ectopic pregnancy in our hospital from May 2016 to January 2018 were selected and divided into two groups by lottery, namely observation group (38 cases) and control group (38 cases). The observation group was treated with mifepristone and methotrexate, while the control group was treated with methotrexate, and the therapeutic effect was compared. Results After treatment, the symptoms of patients in both groups were significantly improved, and the diameter of accessory mass (1.25±0.81)cm,β-HCG (140.25±52.56)U/L in the observation group were lower than those in the control group (1.78±0.52)cm,(290.36±56.94)U/L (P<0.05). The incidence of complications in the observation group was 13.16%, significantly lower than that in the control group 34.21%(P<0.05), and the recovery time of β-HCG to normal (21.25±4.13)d in the observation group was significantly shorter than that in the control group (26.89±4.31)d (P<0.05). Conclusion Mifepristone combined with methotrexate is effective in the treatment of ectopic pregnancy.