TAP 检测在结肠癌癌前病变中的表达及意义

TAP expression in precancerous lesions of colorectal cancer and its significance

目的探讨异常糖链糖蛋白(TAP)在筛查常见消化道疾病结肠腺癌癌前病变中的临床意义。方法连续收集自2012年3月至2014年5月入住本院的结肠炎患者50例、结肠息肉患者50例和结肠腺癌患者50例。收集来自患者指尖的新鲜血液,并对其行TAP检测。结果治疗前结肠炎、结肠息肉和结肠腺癌组患者的TAP阳性表达分别为6%、76%和92%,3组间TAP阳性表达率比较,差异有统计学意义(P<0.05),TAP阳性表达呈上升趋势。TAP阳性表达与性别、年龄和种族无显著相关(P>0.05)。在患有结肠炎和结肠息肉的患者中,TAP阳性患者的肿瘤发生率分别为33.3%、36.8%,TAP阴性患者的肿瘤发生率分别为0、8.3%,两者比较差异有统计学意义(P<0.05),而在结肠癌患者中,TAP阳性患者的术后肿瘤复发率为45%,显著高于TAP阴性组的10%(P<0.05)。结论TAP在结肠腺癌癌前病变中具有更高的表达。另外,TAP参与了从肠黏膜炎症到结肠息肉形成直至组织癌变的整个过程。因此,TAP可用于结肠癌癌前病变的筛查。

Objective To investigate the clinical significance of abnormal sugar-chain glycoprotein tumor abnormal protein (TAP) in the screening of common digestive tract pre-cancer colon adenocarcinoma lesions. Methods A total of 50 colitis patients, 50 colon polyp patients and 50 colon adenocarcinoma patients admitted to our hospital from March, 2012 to May, 2014 were included. Fresh blood from the patients' fingertips was collected;and condensation staining was used to detect TAP expression. Results The positive expressions of TAP in the patients with colitis, colon polyp, and colon adenocarcinoma were 6%, 76%, and 92%, with statistical differences (P < 0.05) and an increasing trend. TAP-positive expression was not significantly correlated with sex, age, and ethnic group (all P > 0.05). Patient follow-up revealed that the tumor incidences in the TAP-positive patients of the ones with colitis, colon polyp, and colon adenocarcinoma were significantly higher than those in the TAP-negative ones (33.3% vs. 0.0%, 36.8% vs. 8.3%, and 45.0% vs. 10.0%;all P < 0.05). Conclusion TAP has a higher expression in colon pre-adenocarcinoma lesions. Additionally, TAP participates in the processes from intestinal mucosal inflammation to colon polyp, and to tissue canceration. Therefore, TAP can be used for the screening of digestive tract precancerous lesions.