摘要
微RNA(miRNA)可调节转录后基因的表达。血浆微RNA的表达在急性心肌梗死患者中显著升高,标志着miRNA在心肌梗死的病理生理机制中发挥重要作用,其中miR-1的过表达可促进心肌梗死后心肌细胞凋亡;miR-126的表达对心肌细胞凋亡有抑制作用;miR-214的高表达对过氧化氢诱导的心肌细胞凋亡具有保护作用。这些研究为治疗心血管疾病提供了新的思路。然而,miRNA作为急性心肌梗死的诊断和预后的生物标志物在应用于临床之前还有诸多问题未能解决,仍需进行大规模深入和系统的研究。
MicroRNAs(miRNAs) regulate the expression of post-transcriptional genes.The expression of plasma microRNA is significantly increased in patients with acute myocardial infarction,which indicates that miRNA plays an important role in the pathophysiological mechanism of myocardial infarction.The overexpression of miR-1 may promote cardiomyocyte apoptosis after myocardial infarction;miR-126 expression has an inhibitory effect on cardiomyocyte apoptosis;high expression of miR-214 has protective effect on hydrogen peroxide-induced cardiomyocyte apoptosis.These studies provide new ideas for the treatment of cardiovascular diseases.However,there are still many problems not solved for miRNAs to be used as biomarkers for the diagnosis and prognosis of acute myocardial infarction,and large-scale in-depth and systematic research is still needed.
作者
伍斌
王军奎
WU Bin;WANG Junkui(Department of Cardiology,Xi′an Medical University,Xi′an 710032,China;Department One of Cardiology,Shaanxi Provincial People′s Hospital,Xi′an 710068,China)
出处
《医学综述》
2019年第13期2579-2582,2587,共5页
Medical Recapitulate
