S100P在消化系统肿瘤中的临床价值

Clinical Value of S100P in Digestive System Tumors

S100P属于钙结合蛋白S100家族成员,在多种恶性肿瘤中异常表达。S100P与肿瘤细胞的增殖、浸润、转移密切相关,是驱动肿瘤发生发展的重要基因。目前,消化系统肿瘤的发病率和死亡率逐年升高,严重威胁人类的健康。S100P作为肿瘤早期诊断的重要标志物及潜在的临床治疗靶点,在结直肠癌、胰腺癌、肝癌、胆管癌等多种消化系统肿瘤中异常表达,对其与多种消化系统肿瘤诊断及预后关系的研究将为临床消化系统肿瘤的治疗提供巨大的帮助。

S100P is a member of the S100 family of calcium-binding proteins,and is abnormally expressed in a variety of malignant tumors.It′s found that S100P is closely related to the proliferation,invasion and metastasis of tumor cells,and is an important gene driving the occurrence and development of tumor.Nowadays,the incidence and mortality of digestive system tumors are increasing,which seriously threatens the health of human beings.As an important marker of early diagnosis of tumors and potential target of clinical treatment,S100P is abnormally expressed in colorectal cancer,pancreatic cancer ,liver cancer,cholangiocarcinoma and other digestive system tumors.The study of the relationship between S100P and the diagnosis and prognosis of various digestive system tumors will provide great help for the treatment.