G蛋白偶联受体的研究进展

Research Advances in G Protein Coupled Receptor

G蛋白偶联受体(GPCRs)是细胞信号传导领域的一类重要的蛋白质分子,被广泛应用于生物细胞信号传导研究以及药物筛选开发中。本文综述了GPCR的特征、分类、信号转导机制、在药物筛选开发中应用等研究进展,并对GPCR功能筛选平台、用非放射性实验取代放射性实验、受体二聚化现象、受体结构等研究热点问题进行了讨论与展望。

G protein-coupled receptors (GPCRs) are an important class of protein molecules in the field of cell signaling and are widely used in biological cell signaling research and drug screening development. In this paper, the characteristics, classification, signal transduction mechanism and drug screening development of GPCR were reviewed, and the research hotspots such as GPCR function screening platform, non- radioactive experiments instead of radioactivity experiments, receptor dimerization and receptor structure were discussed.