普拉洛芬滴眼液联合重组牛碱性成纤维细胞生长因子眼用凝胶治疗麻疹性结膜炎的疗效

Efficacy of pranoprofen eye drops combined with recombinant bovine basic fibroblast growth factor eye gel in the treatment of measles conjunctivitis

目的观察普拉洛芬滴眼液联合重组牛碱性成纤维细胞生长因子眼用凝胶治疗麻疹性结膜炎的临床疗效。方法选取本院78例麻疹性结膜炎患者,采用随机数字表法分组,各39例。对照组予以利巴韦林滴眼液+重组牛碱性成纤维细胞生长因子眼用凝胶治疗,观察组予以普拉洛芬滴眼液+重组牛碱性成纤维细胞生长因子眼用凝胶治疗。对比两组临床疗效、症状(畏光、疼痛、结膜充血)消失时间、不良反应发生率。结果观察组治疗总有效率97.44%(38/39)较对照组79.49%(31/39)高(P<0.05);观察组畏光、疼痛、结膜充血消失时间较对照组短(P<0.05);观察组不良反应发生率7.69%(3/39)与对照组5.13%(2/39)对比,差异无统计学意义。结论与利巴韦林滴眼液联合重组牛碱性成纤维细胞生长因子眼用凝胶治疗相比,普拉洛芬滴眼液联合重组牛碱性成纤维细胞生长因子眼用凝胶治疗麻疹性结膜炎,可增强治疗效果,缩短症状消失时间,促进患者康复,不良反应较少,安全性高。

Objective To observe the clinical efficacy of Praprofen eye drops combined with recombinant bovine basic fibroblast growth factor ophthalmic gel in the treatment of rash conjunctivitis. Methods 78 patients with exanthema conjunctivitis were randomly divided into three groups:39 cases in each group. The control group was treated with ribavirin eye drops recombinant bovine basic fibroblast growth factor ophthalmic gel, and the observation group was treated with Praprofen eye drops recombinant bovine basic fibroblast growth factor ophthalmic gel. Comparison of clinical efficacy, symptoms(fear of light, pain, conjunctival congestion) disappearance time, incidence of adverse reactions. Results The total effective rate was 97.44%(38/39) in the observation group and 79.49%(31/39) in the control group(P<0.05), and the time of fear of light, pain and disappearance of conjunctival congestion in the observation group was shorter than that in the control group(P<0.05). The incidence of adverse reactions was 7.69%(3/39) in the observation group and 5.13%(2/39) in the control group, there was no significant difference between the two groups. Conclusion Compared with ribavirin eye drops combined with recombinant bovine basic fibroblast growth factor ophthalmic gel, Praprofen eye drops combined with recombinant bovine basic fibroblast growth factor ophthalmic gel can enhance the therapeutic effect. Shorten the time of disappearance of symptoms, promote the recovery of patients, less adverse reactions, high safety.