食管上段胃黏膜异位的发病率及危险因素研究

Study on the incidence rate of heterotopic gastric mucosa at upper esophagus and the risk factors related with the pathogenesis of heterotopic gastric mucosa

目的研究食管上段胃黏膜异位(HGMUE)发病率和HGMUE发生的危险因素。方法对2016年2月至12月进行电子胃镜检查的男性患者(45~79岁)进行前瞻性观察研究,患者电子胃镜检查前需要填写调查问卷,分析HGMUE的发病率和存在的危险因素。结果纳入检查的958个患者中,检出HGMUE68例(7.09%)。受教育程度与HGMUE的发生呈负相关,大学学历与高中或者高中学历以下比值比为0.321,95%的可信区间为(0.109,0.871)。吸烟与HGMUE的发生呈正相关,长期吸烟者与不吸烟者的比值比为2.91,95%的可信区间为(1.21,6.70);曾经有吸烟史者和无吸烟史者的比值比为1.95,95%的可信区间为(0.919,4.01)。尚未发现烧心、瘾球症或者吞咽困难等症状与HGMUE相关。结论HGMUE在胃镜检查中比较常见,很少引起相应的临床症状。HGMUE的发生与受教育程度呈负相关,与吸烟呈正相关。

Objective To investigate the incidence rate of heterotopic gastric mucosa(HGMUE) at upper esophagus and the risk factors related with the pathogenesis of HGMUE.Methods The prospective stdy was performed in male patients aged 45 ~ 79 years,who underwent routine esophagogastroduodenoscopy in our hospital from February to December of 2016.The questionnaire was filled in by the patients before electronic gastroscopy,and the incidence rate of HGMUE and the risk factors related with the pathogenesis of HGMUE were analyzed.Results Among the 958 patients,68 cases(7.09%) with HGMUE were detected,and the educational background of patients was negatively correlated with the pathogenesis of HGMUE[odds ratio(OR) of advanced degree vs high school or less=0.321;95%,confidence interval(CI)=0.109,0.871].The tobacco was positively correlated with the pathogenesis of HGMUE,with the odds ratio(OR) of long-term smoker vs non smoker=2.91;95% CI=1.21,6.70,and the odds ratio(OR) of former smoker vs non smoker=1.95;95% CI=0.919,4.01.The symptoms including heartburn,globus and dysphagia were not correlated with HGMUE.Conclusion The HGMUE is common in gastroscopy,which seldom causes clinical symptoms.The pathogenesis of HGMUE is negatively correlated with the educational background of patients,which is positively correlated with the smoking.