布地奈德雾化吸入联合孟鲁司特对支气管哮喘患儿呼吸道功能及血清TGF-β2和IL-17水平的影响

Effects of budesonide atomization inhalation combined with montelukast on pulmonary function,serum levels of TGFβ2 and IL17 in children with bronchial asthma

目的观察布地奈德雾化吸入联合孟鲁司特对支气管哮喘患儿的呼吸道功能及血清转化生长因子-β2(TGF-β2)和白介素-17(IL-17)水平的影响。方法收集就诊的临床诊断为支气管哮喘患儿160例,随机分为观察组和对照组,每组80例。观察组采用布地奈德雾化吸入联合孟鲁司特治疗,对照组采用布地奈德雾化吸入治疗,对2组患儿治疗前后的肺功能、血清TGF-β2和IL-17水平进行比较,并比较2组的临床疗效及不良反应发生情况。结果2组患儿的FVC、FEV1和PEF值较治疗前升高,而血清TGF-β2和IL-17水平较治疗前下降,且治疗后观察组的FVC、FEV1和PEF值较对照组高,TGF-β2和IL-17水平较对照组低,差异均有统计学意义(P<0.05)。观察组的临床总有效率为95.0%高于对照组的85.0%,差异有统计学意义(P<0.05);观察组的总不良反应发生率为7.5%与对照组的5.0%比较差异无统计学意义(P>0.05)。结论布地奈德雾化吸入联合孟鲁司特片治疗可有效提高支气管哮喘患儿的临床疗效,改善患者的肺功能,降低血清TGF-β2和IL-17水平,且安全性较高,值得推广应用。

Objective To observe the effects of budesonide atomization inhalation combined with montelukast on pulmonary function,serum levels of TGF-β2 and IL-17 in children with bronchial asthma.Methods A total of 160 children who were diagnosed as bronchial asthma,were randomly divided into observation group(n=80) and control group(n=80).The patients in observation group were treated by budesonide atomization inhalation combined with montelukast,however,the patients in in control group were treated by budesonide atomization inhalation only.The lung function,serum levels of TGF-β2 and IL-17 of the patients in both groups before and after treatment were compared.Moreover,the therapeutic effects and adverse reactions were observed and compared between the two groups.Results After treatment,the levels of FVC,FEV1 and PEE in both groups were increased,however,the the serum levels of TGF-β2 and IL-17 were decreased.The levels of FVC,FEV1 and PEE in observation group were significantly higher than those in control group,however,the serum levels of TGF-β2 and IL-17 in observation group were significantly lower than those in control group(P<0.05).Moreover,the total effective rate in observation group(95.0%) was significantly higher than that(85.0%) in control group(P<0.05).In addition,there was no significant difference in the total incidence rate of adverse reactions between observation group and control group(7.5% vs 5.0%,P > 0.05).Conclusion The budesonide atomization inhalation combined with montelukast can effectively improve the clinical curative effects on bronchial asthma in children,improve lung function and reduce serum levels of TGF-β2 and IL-17,with higher safety,which is worth using widely in clinical practice.