尿毒清、阿托伐他汀对糖尿病肾病维持性血液透析患者微炎性反应的影响

Effects of uremic clearance and atorvastatin on micro-inflammatory response in patients with diabetic nephropathy during maintenance hemodialysis

目的探析对糖尿病肾病维持性血液透析患者施以尿毒清联合阿托伐他汀用药的治疗疗效。方法96例糖尿病肾病维持性血液透析患者资料,以贯序法分成参照组与试验组,予以参照组常规透析+基础治疗,试验组外施以尿毒清、阿托伐他汀联合用药;评估2组治疗前后微炎性因子、血脂水平及治疗疗效。结果治疗后,试验组微炎性因子、LDL-C、TC、TG水平均参照组较低(P<0.05),HDL-C水平较参照组高(P<0.05);试验组治疗疗效优于参照组(P<0.05)。结论对糖尿病肾病维持性血液透析患者施以尿毒清联合阿托伐他汀用药,可以有效改善微炎症与血脂水平,临床疗效较为显著,因此能够大力实践与推及。

Objective To investigate the curative effects uremic clearance and atorvastatin in treatment of patients with diabetic nephropathy during maintenance hemodialysis.Methods A total of 96 patients with diabetic nephropathy during maintenance hemodialysis in our hospital from August 2016 to November 2017 were enrolled in the study,who were divided into reference group and experimental group according to sequential method.The patients in reference group were treated by routine dialysis + basic treatment,however,the patients in experimental group,on the basis of reference group,were treated by uremic clearance combined with atorvastatin.The micro-inflammatory factors,blood lipid levels and therapeutic effects were observed and compared between the two groups.Results After treatment,the levels of micro inflammatory factors,LDL-C,TC,TG in experimental group were significantly lower than those in reference group(P<0.05),however,the levels of HDL-C in experimental group were significantly higher than those in reference group(P<0.05).Moreover the therapeutic effects in experimental group were superior to those in reference group(P<0.05).Conclusion The application of uremic clearance combined with atorvastatin in treatment of patients with diabetic nephropathy during maintenance hemodialysis can effectively improve the levels of microinflammation and blood lipids,and its clinical curative effects are relatively significant,therefore,which is worthy of promotion in clinical practice.