沙库巴曲缬沙坦治疗老年及盐敏感性高血压的新进展

New Progress of Sacubitril/Valsartan in Treatment of Elderly Hypertension and Salt-sensitive Hypertension

沙库巴曲缬沙坦作为一种新型的血管紧张素受体脑啡肽酶抑制剂,兼有抑制脑啡肽酶与血管紧张素受体的双重作用,现已被国内外的指南推荐代替血管紧张素转换酶抑制剂或血管紧张素Ⅱ受体阻滞剂用于治疗射血分数降低的心力衰竭。同时沙库巴曲缬沙坦显著的降压作用也为其治疗高血压提供了可能。近年来有研究表明,沙库巴曲缬沙坦在老年高血压和盐敏感性高血压的治疗中展现出了独特的优势。现就沙库巴曲缬沙坦在高血压治疗中的作用机制、在老年及盐敏感性高血压中的应用以及安全性与耐受性做一简要阐述。

As a new type of angiotensin receptor neprilysin inhibitor, sacubitril/valsartan has the dual role of inhibiting neprilysin and angiotensin receptor,and it has been recommended by domestic and foreign guidelines to replace angiotensin converting enzyme inhibitor or angiotensin Ⅱ receptor blocker for the treatment of heart failure with reduced ejection fraction.At the same time,the significant antihypertensive effect of sacubitril/valsartan also makes it possible to treat hypertension. In recent years, some studies have shown that sacubitril/valsartan has many unique advantages in treatment of elderly hypertension and salt-sensitive hypertension. This article reviews the mechanism in treatment of hypertension,the application in treatment of elderly hypertension and salt-sensitive hypertension, and safety and tolerability of sacubitril/valsartan.