DNA纳米机器及其核酸传感应用

DNA nanomachines and their applications in nucleic acid sensors

DNA纳米机器是由系列功能核酸序列组成的一类分子机器,由剪切作用和链置换反应驱动,可以在纳米轨道上实现物质的运输。DNA纳米机器易于构建与表征,其结构可以根据需要自由设计且变化可控,因而受到科研工作者的广泛关注。文章概述了DNA纳米机器近几十年来的发展与应用,重点探讨了DNA walker、DNA tweezer、DNA motor三种纳米机器以及它们在核酸传感器中的应用。

DNA nanomachines are a class of molecular machines consisting of a series of functional nucleic acid sequences, driven by cleavage and strand displacement reactions, to transport materials in nano -track. DNA nanomachines are easy to construct and characterize, and their structures can be freely designed and controlled according to our needs, which has attracted wide attention from researchers. This article outlines the development and application of DNA nanomachines in recent decades, giving focus on three nanomachines about DNA walker, DNA tweezer, and DNA motor and their applications in nucleic acid sensors.