刘丽芳教授治疗乳腺增生症用药规律研究

Research on Professor LIU Lifang’s Medication Rules in the Treatment of Mammary Gland Hyperplasia

目的总结刘丽芳教授诊疗乳腺增生症的临床用药经验并归纳探讨其遣方用药规律。方法收集并整理刘丽芳教授临床辨证论治乳腺增生症处方,进行勘误后建立乳腺增生症遣方用药数据库,于数据库基础上运用软件集成数据挖掘方法,对所选处方进行用药频次统计、用药模式及配伍关联规则分析。结果共纳入门诊病历处方197份,总用药频次为3349次,共使用61味药,17味核心药物,其中药物出现频次以理气药及活血药为主,处方中所出现药物归经分布多为肝、脾、心、肾等经,按出现频数四气分布依次为温、凉、寒、平,五味分布依次为苦、辛、甘;确定药物之间关联规则,进行统计分析后获得用药规律(模式)24条(其中对药模式19条、3味药模式5条),并得到新处方3个。结论刘丽芳教授治疗乳腺增生症以辨证论治为基础,所采用药物以理气活血药、化痰散结药、养血健脾药为主,兼顾患者体质,注重整体审察,并辅之行气活血、化痰散结、养血健脾等治法,将病证结合贯穿于治疗的全过程。

Objective To summarize the clinical medication experience of Professor LIU Lifang in the diagnosis and treatment of mammary gland hyperplasia and to explore her medication rules.Methods Professor LIU Lifang's clinical prescriptions due to syndrome differentiation and treatment in mammary gland hyperplasia were collected and organized.After the errata, a database of prescriptions for mammary gland hyperplasia was established.Based on the database, software integration and data mining methods were used to calculate the medication frequency of selected prescriptions, and analyze the medication mode and compatibility association rules.Results Through the analysis of 197 outpatient prescriptions, the total frequency of medication was 3,349 times.A total of 61 Chinese medicinal materials (CMM) and 17 core CMM were used.According to the frequency of CMM, those for regulating Qi and activating blood were frequently used.The distribution of drug return is mostly liver, spleen, heart, kidney, etc.The CMM in the prescriptions mainly enter the liver, spleen, heart and kidney channels, The distribution of four natures is warm, cool, cold and flat according to the frequency of occurrence, while the distribution of five flavors is bitter, pungent and sweet.Association rules were determined, and after the statistical analysis, 24 rules of medication (mode) were obtained (among which, 19 were 2-drug modes, 5 were 3-drug modes), and 3 new prescriptions were determined.Conclusion Professor LIU Lifang treats mammary gland hyperplasia based on syndrome differentiation and treatment.The CMM used are mainly for regulating Qi and activating blood, dissipating phlegm and resolving masses, as well as nourishing blood and invigorating spleen, taking the patient's constitution into account and paying attention to the overall examination.And supplemented methods like regulating Qi and invigorating blood, dissipating phlegm and resolving masses, as well as nourishing blood and invigorating spleen, with the integration of disease and syndrome throughout the entire process of the treatment for mammary gland hyperplasia.