同型半胱氨酸和超敏C反应蛋白在下肢深静脉血栓诊断中的应用

Application of Homocysteine and High-sensitivity C-reactive Protein in the Diagnosis of Deep Venous Thrombosis of Lower Extremities

目的研究与分析同型半胱氨酸和超敏C反应蛋白在下肢深静脉血栓诊断中的应用价值。方法选取该院2017年8月-2018年12月收治下肢骨折疾病患者82例,根据患者术后是否出现下肢深静脉血栓的情况进行分组,其中43例出现下肢深静脉血栓疾病的患者作为研究组,39例未出现下肢深静脉血栓疾病的患者作为对照组,分别在术后1d,2d以及3d对两组研究者采用胶乳增强免疫比浊法来检测患者的同型半胱氨酸和超敏C反应蛋白等指标,同时观察两组患者的相关凝血功能指标。结果研究组与对照组患者术后2 d,3 d的同型半胱氨酸和超敏C反应蛋白等指标差异显著,研究组患者的各项指标均较高(17.1±1.9)mol/L,(16.4±1.6)mol/L,(38.5±3.8)mg/L,(35.5±3.3)mg/L vs (9.3±1.4)mol/L,(8.9±1.4)mol/L,(15.5±1.5)mg/L,(19.3±1.9)mg/L,差异有统计学意义(t=21.672 1,23.132 7,35.158 6,26.568 2,P<0.05)。研究组与对照组患者术后1 d的凝血酶原时间以及活化部分凝血活酶时间等指标差异无统计学意义(t=0.395 4,P>0.05)。而研究组与对照组患者术后2d,3d的凝血酶原时间以及活化部分凝血活酶时间等指标差异显著,研究组患者的各项指标均较高(16.7±1.2)s,(46.3±2.3)s,(16.2±1.0)s,(44.8±2.5)s vs (13.8±1.3)s,(38.3±1.9)s,(13.8±1.4)s,(38.3±1.9)s,差异有统计学意义(t=10.504 4,17.069 9,8.994 8,13.151 1,P<0.05)。结论同型半胱氨酸和超敏C反应蛋白在下肢深静脉血栓诊断中的应用价值较高,可以在临床上加以推广与使用。

Objective To study and analyze the value of homocysteine and high-sensitivity C-reactive protein in the diagnosis of deep venous thrombosis of lower extremities. Methods A total of 82 patients with lower extremity fractures were enrolled from August 2017 to December 2018 in our hospital. According to whether there were deep venous thrombosis in the lower limbs, 43 patients with deep venous thrombosis of the lower extremities were studied. In the control group, 39 patients with no deep venous thrombosis of the lower extremities were used as the control group. The mice were tested for homocysteine and hypersensitivity by latex-enhanced immuno-turbidimetry at 1 day, 2 days and 3 days after surgery. C-reactive protein and other indicators, while observing the relevant coagula-tion function indicators in the two groups of patients. Results There were significant differences in the expression of homocysteine and high-sensitivity C-reactive protein between the study group and the control group at 2 and 3 days after operation. The indexes of the study group were higher(17.1 ±1.9)mol/L,(16.4±1.6)mol/L,(38.5 ±3.8)mg/L,(35.5 ±3.3)mg/L vs(9.3 ±1.4)mol/L,(8.9 ±1.4)mol/L,(15.5±1.5)mg/L,(19.3±1.9)mg/L. The difference was statistically significant(t=21.672 1, 23.132 7, 35.158 6, 26.568 2, P<0.05).There was no significant difference in the prothrombin time and activated partial thromboplastin time between the study group and the control group at 1 day after surgery, and the difference was not statistically significant(t=0.395 4, P>0.05). The indexes of prothrombin time and activated partial thromboplastin time were significantly different between the study group and the control group at 2 days and 3 days after operation. The indexes of the study group were higher(16.7 ±1.2)s,(46.3±2.3)s,(16.2±1.0)s,(44.8±2.5)s vs(13.8±1.3)s,(38.3±1.9)s,(13.8±1.4)s,(38.3±1.9)s, the difference was statistically significant(t=10.504 4, 17.069 9, 8.994 8, 13.1511, P<0.05). Conclusion The use of homocysteine and high-sensitivity C-reactive protein in the diagnosis of deep venous thrombosis of lower extremity is high and can be promoted and used clinically.