载脂蛋白E基因多态性与主观认知减退的相关性

Correlation between the Polymorphisms of Apolipoprotein E Gene and Subjective Cognitive Decline

目的:分析载脂蛋白E(ApoE)的多态性与主观认知减退(SCD)的相关性。方法:选取SCD患者130例为SCD组,另选取同期体检的健康人120例为对照组;应用聚合酶链反应检测两组被检者的ApoE基因多态性,分析其与SCD患病之间的相关性。结果:两组被检者常见的基因型均是ε3/ε3,SCD组ε3/4和ε4/4基因型频率高于对照组,差异有统计学意义(χ^2=4.139、4.173,P<0.05);SCD组和对照组被检者ε4等位基因频率分别为17.69%、7.91%,两者比较差异有统计学意义(χ^2=4.421,P=0.036),两组被检者ApoE等位基因频率均以ε3最高(SCD组为75%、对照组为81.67%);ApoEε4等位基因频率与SCD患病呈正相关性(OR=1.922,P=0.036)。结论:ApoEε3/3为最常见的基因型,ApoEε3为最常见的等位基因,ApoEε4基因是SCD患病的重要危险因素。

Objective:To analyze the correlation between apolipoprotein E(ApoE)polymorphism and subjective cognitive decline(SCD).Methods:130 patients with SCD were enrolled as the SCD group,and 120 healthy subjects were recruited as the control group.The polymorphisms of ApoE gene were detected by polymerase chain reaction(PCR).The correlation between ApoE polymorphisms and SCD pateints was analyzed.Results:The most common genotype of the two groups wasε3/ε3.The frequencies ofε3/4 andε4/4 genotypes were higher in SCD group than those in the control group(χ^2=4.139,4.173,P<0.05).Theε4 allele frequencies of the SCD group and the control group were 17.69%and 7.91%,respectively,and the difference was statistically significant(χ^2=4.421,P=0.036).Among ApoE alleles,the frequency ofε3 allele was the highest(75%in SCD group and 81.67%in control group).The frequency ofε4 allele was positively correlated with SCD(OR=1.922,P=0.036).Conclusion:ApoEε3/3 is the most common genotype and Apo Eε3 is the most common allele,and ApoEε4 gene is an important risk factor for SCD.