2,6-二氯嘌呤C6位胺基化反应条件的优化

Optimization of C6 Amination of 2,6-dichloropurine

嘌呤衍生物作为一种研究抗肿瘤、抗病毒的重要医药中间体,吸引了很多研究人员对嘌呤结构进行改造。其中C6位胺基化反应,是嘌呤结构改造的研究热点之一。本文以2,6-二氯嘌呤为原料,经C9位保护后与甲胺胺盐酸盐进行微波反应。通过改变温度、溶剂和反应时间,寻找出了最佳反应条件。

Purine derivatives as a kind of important pharmaceutical research of anti-tumor antiviral,attracted many researchers to modify structure of purine.C6 amination is one of the highlights in the purine structure modifination.In this paper,2,6-dichloropurine was used as the starting material to synthesize the C9 protective compound.Then use C9 protection compound reacted with methylamine hydrochloride and found the optimal reaction conditions by microwave reaction.