桥本甲状腺炎对甲状腺微小乳头状癌的影响及相关因素分析

Influence of Hashimoto’s thyroiditis(HT) on patients with thyroid micropapillary carcinoma(PTC) and analysis of relevant factors

目的探讨桥本甲状腺炎(HT)对甲状腺微小乳头状癌(PTC)患者常见临床资料及实验室指标的影响。方法回顾性分析2010—2018年某院收治的诊断为PTC的173例患者的临床资料,依据是否伴发HT分为伴发组29例和非伴发组144例。对两组患者的一般临床资料和实验室指标进行比较,并进行多因素Logistic回归分析。结果两组患者的年龄、性别、肿瘤直径、包膜侵袭、中央淋巴结转移和促甲状腺激素(TSH)、甲状腺过氧化物酶抗体(TPOAb)差异有统计学意义(P<0.05)。多因素Logistic回归分析显示,年龄、性别、肿瘤直径和TSH是PTC伴发HT的危险因素。结论对于PTC患者中的女性、年龄偏小、肿瘤直径偏小及TSH水平升高的部分患者,要警惕并发HT的风险。

Objective To investigate the effect of Hashimoto's thyroiditis(HT) on the clinical data and laboratory indexes of patients with thyroid micropapillary carcinoma(PTC).Methods The clinical data of 173 cases of thyroid micropapillary carcinoma diagnosed in a hospital from 2010 to 2018 were retrospectively analyzed.According to whether Hashimoto's thyroiditis was accompanied or not,the patients were divided into two groups,29 cases in the concomitant group and 144 cases in the non-concomitant group.The general clinical data and laboratory indexes of the two groups were analyzed and multivariate logistic regression analysis was administered.Results There were significant differences between the two groups in age,sex,tumor diameter,capsular invasion,central lymph node metastasis,TSH and TPOAb(P<0.05).Multivariate logistic regression analysis showed that age,sex,tumor diameter and TSH were risk factors for Hashimoto's thyroiditis associated with thyroid micropapillary carcinoma.Conclusion The risk of HT of young female patients of hyroid micropapillary carcinoma with smaller tumor diameter and elevated TSH level was higher.