白藜芦醇通过TGF-β信号通路对肠黏膜屏障功能的调控

Regulation of resveratrol on intestinal mucosal barrier function based on TGF-β signaling pathway

肠道健康水平对动物整体健康水平十分重要。作为机体抵御致病抗原入侵的防线,肠黏膜屏障的完整性极易受到损害。白藜芦醇是一种多酚类抗毒素,主要通过抗炎、抗纤维化、抗氧化等多种途径,对肠道黏膜屏障损伤及功能障碍发挥作用。转化生长因子-β(TGF-β)是一种多功能细胞因子,具有与白藜芦醇相似的功能。白藜芦醇可以通过对TGF-β/Smads信号通路的调控来影响肠道的健康。文章综述了白藜芦醇和TGF-β对肠黏膜屏障功能的作用以及白藜芦醇通过TGF-β信号通路对肠道健康的调控方式,为白藜芦醇在动物生产中的应用提供参考。

Intestinal health is very important for the overall health of animals.As the defense against invasion of pathogenic antigens,the integrity of intestinal mucosal barrier is vulnerable to be damaged.Resveratrol(Res),a polyphenolic phytoalexin,is effective in regulating immunity and protecting intestinal barrier through anti-inflammatory,anti-oxidative,anti-proliferative and other ways.Transforming growth factor-β(TGF-β)is one of the pleiotropic cytokines that also displays such properties as Res.Res can regulate intestinal health through the TGF-β/Smads signaling pathway.The effects of resveratrol and TGF-βon intestinal mucosal barrier function and the regulation of resveratrol through TGF-βsignaling pathway on intestinal health were reviewed,so as to provide reference for the application of resveratrol in animal production.