摘要
使用18-氟标记的氟脱氧葡萄糖(18F-fluorodeoxyglucose,18F-FDG)正电子发射断层扫描结合计算机断层扫描(PET/CT)的功能显像在霍奇金淋巴瘤(Hodgkin lymphoma,HL)的分期中具有明确的作用,现已成为HL的主要显像模式。其作为一种预测治疗工具,通过反应适应疗法的应用而不断发展。已有大量临床研究表明18F-FDGPET/CT对HL具有非常高的预后诊断价值,可以提高分期的准确性,鉴别残留肿瘤和纤维化组织。HL中的反应适应性治疗方法既可以通过减低剂量来降低对低风险患者的毒性,同时还通过增加对高风险患者的治疗强度以改善预后。本综述介绍了18F-FDGPET/CT在HL中的诊断分期、治疗期间和治疗结束时的应用进展,并对总肿瘤代谢体积这一新的功能预后因素进行了探讨。
Functional imaging using 18-fluorodeoxyglycose(18F-FDG)positron emission tomography combined with computed tomography(PET/CT)has become a major imaging modality in Hodgkin lymphoma with a definite role in the staging of Hodgkin lymphoma.It is a predictive treatment tool that is constantly evolving through the use of response-adaptive therapies.A large number of clinical studies have shown that 18 F-FDG PET/CT has a very high prognostic value for HL,which can improve the accuracy of staging and identify residual tumors and fibrotic tissues.The response-adaptive treatment in HL can reduce the toxicity to low-risk patients by reducing the dose,and also improve the prognosis by increasing the intensity of treatment for high-risk patients.This review describes the application of 18 F-FDG PET/CT to the diagnosis,staging and end of treatment in HL,and explores the new functional prognostic factors for total metabolic tumor volume.
作者
贾茜婷
贾韬
Jia Xiting;Jia Tao(Lianyungang Clinical Medical College Affiliated to Nanjing Medical University,Lianyungang First People's Hospital,Lianyungang 222000,China)
出处
《临床荟萃》
CAS
2019年第6期519-524,共6页
Clinical Focus
