营养状况对肺癌化疗患者所致恶心呕吐的影响

Effect of nutritional status on nausea and vomiting caused by chemotherapy in patients with lung cancer

目的探讨营养状况对以顺铂为基础化疗的肺癌患者所致化疗相关性恶心呕吐(CINV)的影响。方法选取常州市第一人民医院采用顺铂化疗的肺癌住院患者200例,均选用昂丹司琼作为止吐药物,根据营养评定量表(PG-SGA)评分分为营养不良组,无营养不良组,分析两组临床资料、营养相关指标、CINV。对存在营养不良的患者进行营养干预,比较营养干预前后CINV持续时间。结果纳入的200例患者中PG-SGA评分≥4分122例,61%的患者存在营养不良。两组性别、年龄、肿瘤类型、肿瘤分期、化疗方案等临床资料差异均无统计学意义(P>0.05)。多因素回归分析营养不良是CINV的独立危险因素。对存在营养不良的患者进行营养干预后,恶心呕吐持续时间较前改善(P<0.01)。结论营养不良是CINV的独立危险因素,进行营养干预可改善CINV持续时间。

Objective To investigate the effect of nutritional status on chemotherapy-induced nausea and vomiting by cisplatin-based chemotherapy in patients with lung cancer.Methods A total of 200 patients with lung cancer who received cisplatin chemotherapy in the First People's Hospital of Changzhou was selected,and ondansetron was used as antiemetic drug.All patients are divided into a malnutrition group and a non-malnutrition group according to PG-SGAscore,and the clinical data,nutrition-related indicators,and CINV were analysed.Nutritional intervention was performed on malnourished patients,and the duration of CINV before and after nutritional intervention was compared.Results Among the 200 patients included,the PG-SGA score was≥4 points in 122 cases,which indicated that 61%of the 200 patients had malnutrition.There were no significant differences in clinical data between the two groups in terms of gender,age,tumor type,tumor stage,and chemotherapy regimen(P>0.05).Multivariate regression analysis showed that malnutrition was an independent risk factor for CINV(P<0.01).After nutritional intervention in patients with malnutrition,the duration of nausea and vomiting was improved(P<0.01).Conclusion Malnutritionisan is independent risk factor for CINV,and nutritional intervention can improve the duration of CINV.